An improved oxadiazole synthesis using peptide coupling reagents

被引：81

作者：

Liang, GB

Feng, DD

机构：

[1] Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(96)01492-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted 1,2,4-oxadiazoles were synthesized in good yields in a one pot procedure by condensation of the corresponding amidoxime with carboxylic acids in the presence of a peptide coupling reagent in diglyme. followed by heating the reaction mixture to 100 degrees C for several hours. Copyright (C) 1996 Elsevier Science Ltd

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页码：6627 / 6630

页数：4

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