Effects of aging on neuromagnetic mismatch responses to pitch changes

被引：26
作者：
Cheng, Chia-Hsiung [1 ,5 ,6 ,9 ]
Baillet, Sylvain [9 ]
Hsiao, Fu-Jung [1 ,8 ]
Lin, Yung-Yang [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Dept Neurol, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan
[4] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
[5] Taipei Vet Gen Hosp, Neurophysiol Lab, Taipei 112, Taiwan
[6] Taipei Vet Gen Hosp, Integrated Brain Res Lab, Taipei 112, Taiwan
[7] Taipei Vet Gen Hosp, Dept Neurol, Taipei 112, Taiwan
[8] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan
[9] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Dynam Neuroimaging Lab, Montreal, PQ, Canada
来源：
NEUROSCIENCE LETTERS | 2013年 / 544卷
关键词：
Aging; Auditory sensory memory; Mismatch negativity (MMN); Involuntary attention switch; Magnetoencephalography (MEG); AUDITORY SELECTIVE ATTENTION; EVENT-RELATED POTENTIALS; AGE-RELATED-CHANGES; SENSORY MEMORY; ELDERLY SUBJECTS; NEGATIVITY; BRAIN; YOUNG; DURATION; STIMULI;
D O I：
10.1016/j.neulet.2013.02.063
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mismatch activity to pitch deviants by using a whole-head magnetoencephalography (MEG) together with distributed source modeling analysis. The neuromagnetic responses to oddball paradigms consisting of standards (1000 Hz, p = 0.85) and deviants (1100 Hz, p = 0.15) were recorded in healthy young (n = 20) and aged (n = 18) male adults. We used minimum norm estimate of source reconstruction to characterize the spatiotemporal neural dynamics of MMNm responses. Distributed activations to MMNm were identified in the bilateral fronto-temporo-parietal areas. Compared to younger participants, the elderly exhibited a significant reduction of cortical activation in bilateral superior temporal guri, superior temporal sulci, inferior fontal gyri, orbitofrontal cortices and right inferior parietal lobules. In conclusion, our results suggest an aging-related decline in auditory sensory memory and automatic change detection as indexed by MMNm. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：20 / 24
页数：5
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