Feast or famine: the host-pathogen battle over amino acids

被引：97

作者：

Zhang, Yanjia J. ^{[1
]}

Rubin, Eric J. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

CELLULAR MICROBIOLOGY | 2013年 / 15卷 / 07期

关键词：

DEPENDENT SALMONELLA-TYPHIMURIUM; BACTERIAL SIGNAL MOLECULE; MYCOBACTERIUM-TUBERCULOSIS; LEGIONELLA-PNEUMOPHILA; GAMMA-INTERFERON; STRINGENT RESPONSE; INDOLEAMINE 2,3-DIOXYGENASE; TOXOPLASMA-GONDII; STATIONARY-PHASE; TRYPTOPHAN DEGRADATION;

D O I：

10.1111/cmi.12140

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity. Here we discuss both host mechanisms of amino acid starvation and the diverse adaptations of pathogens to their nutrient-deprived environments. These processes provide both key insights into immune subversion and new targets for drug development.

引用

页码：1079 / 1087

页数：9

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