Fitness of bacteria is determined both by how fast cells grow when nutrients are abundant and by how well they survive when conditions worsen. Here, we study how prior growth conditions affect the death rate ofEscherichia coliduring carbon starvation. We control the growth rate prior to starvation either via the carbon source or via a carbon-limited chemostat. We find a consistent dependence where death rate depends on the prior growth conditions only via the growth rate, with slower growth leading to exponentially slower death. Breaking down the observed death rate into two factors, maintenance rate and recycling yield, reveals that slower growing cells display a decreased maintenance rate per cell volume during starvation, thereby decreasing their death rate. In contrast, the ability to scavenge nutrients from carcasses of dead cells (recycling yield) remains constant. Our results suggest a physiological trade-off between rapid proliferation and long survival. We explore the implications of this trade-off within a mathematical model, which can rationalize the observation that bacteria outside of lab environments are not optimized for fast growth.
机构:
Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
Basan, Markus
Hui, Sheng
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机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
Hui, Sheng
Williamson, James R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
ETH, Inst Mol Syst Biol, CH-8093 Zurich, SwitzerlandUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Basan, Markus
Hui, Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Hui, Sheng
Okano, Hiroyuki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Okano, Hiroyuki
Zhang, Zhongge
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Zhang, Zhongge
Shen, Yang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Shen, Yang
Williamson, James R.
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h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Williamson, James R.
Hwa, Terence
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h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA
ETH, Inst Theoret Studies, CH-8092 Zurich, SwitzerlandUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Erickson, David W.
Schink, Severin J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Tech Univ Munich, Phys Dept, Phys Complex Biosyst, D-85748 Garching, GermanyUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Schink, Severin J.
Patsalo, Vadim
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h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Patsalo, Vadim
Williamson, James R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Williamson, James R.
Gerland, Ulrich
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机构:
Tech Univ Munich, Phys Dept, Phys Complex Biosyst, D-85748 Garching, GermanyUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Gerland, Ulrich
Hwa, Terence
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
机构:
Univ So Calif, Dept Sci Biol, Mol & Computat Biol Programme, Los Angeles, CA 90089 USAUniv So Calif, Dept Sci Biol, Mol & Computat Biol Programme, Los Angeles, CA 90089 USA
机构:
Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
Basan, Markus
Hui, Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
Hui, Sheng
Williamson, James R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA
Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USAHarvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
ETH, Inst Mol Syst Biol, CH-8093 Zurich, SwitzerlandUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Basan, Markus
Hui, Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Hui, Sheng
Okano, Hiroyuki
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Okano, Hiroyuki
Zhang, Zhongge
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Zhang, Zhongge
Shen, Yang
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Shen, Yang
Williamson, James R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Williamson, James R.
Hwa, Terence
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA
ETH, Inst Theoret Studies, CH-8092 Zurich, SwitzerlandUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Erickson, David W.
Schink, Severin J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Tech Univ Munich, Phys Dept, Phys Complex Biosyst, D-85748 Garching, GermanyUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Schink, Severin J.
Patsalo, Vadim
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Patsalo, Vadim
Williamson, James R.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, Skaggs Inst Chem Biol, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Williamson, James R.
Gerland, Ulrich
论文数: 0引用数: 0
h-index: 0
机构:
Tech Univ Munich, Phys Dept, Phys Complex Biosyst, D-85748 Garching, GermanyUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
Gerland, Ulrich
Hwa, Terence
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
机构:
Univ So Calif, Dept Sci Biol, Mol & Computat Biol Programme, Los Angeles, CA 90089 USAUniv So Calif, Dept Sci Biol, Mol & Computat Biol Programme, Los Angeles, CA 90089 USA