Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima

被引：13

作者：

Ha Kim, Byoung ^{[1
]}

Lee, Won-Yung ^{[2
]}

Trinh, Tuy An ^{[2
]}

Pyo, Jae Sung ^{[3
]}

Lee, Sooyeun ^{[4
]}

Kim, Chang-Eop ^{[2
]}

Lee, Dong Hwan ^{[5
]}

Park, Eun-Seok ^{[6
]}

Kang, Ki Sung ^{[2
]}

机构：

[1] D Nat Co Ltd, Seongnam 13174, South Korea

[2] Gachon Univ, Coll Korean Med, Seongnam 13120, South Korea

[3] Kyungsung Univ, Coll Pharm, Busan 48434, South Korea

[4] Keimyung Univ, Coll Pharm, 1095 Dalgubeoldaero, Daegu 42601, South Korea

[5] GFC Life Sci Co Ltd, Korea Dermatol Res Inst, Seongnam 13517, South Korea

[6] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea

来源：

PROCESSES | 2020年 / 8卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

hair growth; brevilin A; Centipeda minima; Janus kinase-signal transducer and activator of transcription signaling pathway; network pharmacology; ALOPECIA-AREATA; CONSTITUENTS; GENE; KEGG;

D O I：

10.3390/pr8070767

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Janus kinase 3 (JAK3) inhibitors have been used effectively in the treatment of several cases of alopecia universalis and its variants. Our study aims to evaluate whether the emulsion extract of brevilin A fromCentipeda minima(CMX) stimulates hair regrowth in a clinical trial, as a JAK3 inhibitor, combined with network pharmacology-based analysis. CMX showed potent inhibition of JAK3 in a concentration-dependent manner. Significant differences in total hair count, terminal hair count, and anagen hair count from the baseline to 24 weeks were observed between the placebo and CMX subjects. The gene set enrichment analysis showed that the targets of CMX are mainly associated with the JAK-STAT signaling pathway, cytokine-cytokine receptor interactions, and the MAPK signaling pathway. This study suggests that the medicinal herbal extract CMX is useful in the treatment of mild to moderate vertex balding that contribute to the visible improvements in hair growth observed in treated patients.

引用

页数：14

共 33 条

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