FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

被引:20
作者
Burkett, Zachary Daniel [1 ,2 ]
Day, Nancy F. [1 ]
Kimball, Todd Haswell [1 ,3 ]
Aamodt, Caitlin M. [1 ,4 ]
Heston, Jonathan B. [1 ,4 ]
Hillliard, Austin T. [5 ]
Xiao, Xinshu [1 ,2 ]
White, Stephanie A. [1 ,2 ,4 ]
机构
[1] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Interdept Program Mol Cellular & Integrat Physiol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Physiol Sci Master Degree Program, Los Angeles, CA USA
[4] Univ Calif Los Angeles, Interdept Program Neurosci, Los Angeles, CA USA
[5] Stanford Univ, Dept Biol, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
BASAL GANGLIA; HUMAN SPEECH; AREA-X; PROTEIN; SONGBIRD; BRAIN; EXPRESSION; ORGANIZATION; VARIABILITY; BIRDSONG;
D O I
10.7554/eLife.30649
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human speech is one of the few examples of vocal learning among mammals yet half of avian species exhibit this ability. Its neurogenetic basis is largely unknown beyond a shared requirement for FoxP2 in both humans and zebra finches. We manipulated FoxP2 isoforms in Area X, a song-specific region of the avian striatopallidum analogous to human anterior striatum, during a critical period for song development. We delineate, for the first time, unique contributions of each isoform to vocal learning. Weighted gene coexpression network analysis of RNA-seq data revealed gene modules correlated to singing, learning, or vocal variability. Coexpression related to singing was found in juvenile and adult Area X whereas coexpression correlated to learning was unique to juveniles. The confluence of learning and singing coexpression in juvenile Area X may underscore molecular processes that drive vocal learning in young zebra finches and, by analogy, humans.
引用
收藏
页数:35
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