Dietary modification and supplementation for the treatment of age-related macular degeneration

被引：39
作者：
Broadhead, Geoffrey K. [1 ,2 ]
Grigg, John R. [1 ]
Chang, Andrew A. [1 ,2 ]
McCluskey, Peter [1 ]
机构：
[1] Univ Sydney, Dept Ophthalmol, Save Sight Inst, Sydney, NSW 2000, Australia
[2] Sydney Inst Vis Sci, Sydney, NSW 2000, Australia
来源：
NUTRITION REVIEWS | 2015年 / 73卷 / 07期
关键词：
Age-related macular degeneration; antioxidants; diet; dietary supplements; PIGMENT OPTICAL-DENSITY; COMPLEMENT FACTOR-H; LONG-TERM INCIDENCE; EYE DISEASE; GLYCEMIC INDEX; LUTEIN SUPPLEMENTATION; VISUAL PERFORMANCE; RISK-FACTORS; VITAMIN-E; GENETIC SUSCEPTIBILITY;
D O I：
10.1093/nutrit/nuv005
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Age-related macular degeneration (AMD) causes a significant proportion of visual loss in the developed world. Currently, little is known about its pathogenesis, and treatment options are limited. Dietary intake is one of the few modifiable risk factors for this condition. The best-validated therapies remain oral antioxidant supplements based on those investigated in the Age-Related Eye Disease Study (AREDS) and the recently completed Age-Related Eye Disease Study 2 (AREDS2). In this review, current dietary guidelines related to AMD, along with the underlying evidence to support them, are presented in conjunction with current treatment recommendations. Both AREDS and AREDS2 are discussed, as are avenues for further research, including supplementation with vitamin D and saffron. Despite the considerable disease burden of atrophic AMD, few effective therapies are available to treat it, and further research is required.
引用
收藏
页码：448 / 462
页数：15
相关论文
共 139 条
[71]   Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance [J].
Kvansakul, Jessica ;
Rodriguez-Carmona, Marisa ;
Edgar, David F. ;
Barker, Felix M. ;
Koepcke, Wolfgang ;
Schalch, Wolfgang ;
Barbur, John L. .
OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 2006, 26 (04) :362-371
[72]   Macular pigment density and age-related maculopathy in the carotenoids in age-related eye disease study - An ancillary study of the women's health initiative [J].
LaRowe, Tara L. ;
Mares, Julie A. ;
Snodderly, D. Max ;
Klein, Michael L. ;
Wooten, Billy R. ;
Chappell, Richard .
OPHTHALMOLOGY, 2008, 115 (05) :876-883
[73]   Advice about diet and smoking for people with or at risk of age-related macular degeneration: a cross-sectional survey of eye care professionals in the UK [J].
Lawrenson, John G. ;
Evans, Jennifer R. .
BMC PUBLIC HEALTH, 2013, 13
[74]   Omega 3 fatty acids for preventing or slowing the progression of age-related macular degeneration [J].
Lawrenson, John G. ;
Evans, Jennifer R. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (11)
[75]  
Lonn E, 2005, JAMA-J AM MED ASSOC, V293, P1338, DOI 10.1001/jama.293.11.1338
[76]   The Impact of Macular Pigment Augmentation on Visual Performance Using Different Carotenoid Formulations [J].
Loughman, James ;
Nolan, John M. ;
Howard, Alan N. ;
Connolly, Eithne ;
Meagher, Katie ;
Beatty, Stephen .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (12) :7871-7880
[77]   The relationship between macular pigment and visual performance [J].
Loughman, James ;
Akkali, Mukunda C. ;
Beatty, Stephen ;
Scanlon, Grainne ;
Davison, Peter A. ;
O'Dwyer, Veronica ;
Cantwell, Tom ;
Major, Philip ;
Stack, Jim ;
Nolan, John M. .
VISION RESEARCH, 2010, 50 (13) :1249-1256
[78]   Effect of Lutein and Zeaxanthin on Macular Pigment and Visual Function in Patients with Early Age-related Macular Degeneration [J].
Ma, Le ;
Yan, Shao-Fang ;
Huang, Yang-Mu ;
Lu, Xin-Rong ;
Qian, Fang ;
Pang, Hong-Lei ;
Xu, Xian-Rong ;
Zou, Zhi-Yong ;
Dong, Peng-Cheng ;
Xiao, Xin ;
Wang, Xun ;
Sun, Ting-Ting ;
Dou, Hong-Liang ;
Lin, Xiao-Ming .
OPHTHALMOLOGY, 2012, 119 (11) :2290-2297
[79]   Improvement of Retinal Function in Early Age-Related Macular Degeneration After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial [J].
Ma, Le ;
Dou, Hong-Liang ;
Huang, Yang-Mu ;
Lu, Xin-Rong ;
Xu, Xian-Rong ;
Qian, Fang ;
Zou, Zhi-Yong ;
Pang, Hong-Lei ;
Dong, Peng-Cheng ;
Xiao, Xin ;
Wang, Xun ;
Sun, Ting-Ting ;
Lin, Xiao-Ming .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2012, 154 (04) :625-634
[80]   Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis [J].
Ma, Le ;
Dou, Hong-Liang ;
Wu, Yi-Qun ;
Huang, Yang-Mu ;
Huang, Yu-Bei ;
Xu, Xian-Rong ;
Zou, Zhi-Yong ;
Lin, Xiao-Ming .
BRITISH JOURNAL OF NUTRITION, 2012, 107 (03) :350-359
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