Dietary modification and supplementation for the treatment of age-related macular degeneration

被引：39

作者：

Broadhead, Geoffrey K. ^{[1
,2
]}

Grigg, John R. ^{[1
]}

Chang, Andrew A. ^{[1
,2
]}

McCluskey, Peter ^{[1
]}

机构：

[1] Univ Sydney, Dept Ophthalmol, Save Sight Inst, Sydney, NSW 2000, Australia

[2] Sydney Inst Vis Sci, Sydney, NSW 2000, Australia

来源：

NUTRITION REVIEWS | 2015年 / 73卷 / 07期

关键词：

Age-related macular degeneration; antioxidants; diet; dietary supplements; PIGMENT OPTICAL-DENSITY; COMPLEMENT FACTOR-H; LONG-TERM INCIDENCE; EYE DISEASE; GLYCEMIC INDEX; LUTEIN SUPPLEMENTATION; VISUAL PERFORMANCE; RISK-FACTORS; VITAMIN-E; GENETIC SUSCEPTIBILITY;

D O I：

10.1093/nutrit/nuv005

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Age-related macular degeneration (AMD) causes a significant proportion of visual loss in the developed world. Currently, little is known about its pathogenesis, and treatment options are limited. Dietary intake is one of the few modifiable risk factors for this condition. The best-validated therapies remain oral antioxidant supplements based on those investigated in the Age-Related Eye Disease Study (AREDS) and the recently completed Age-Related Eye Disease Study 2 (AREDS2). In this review, current dietary guidelines related to AMD, along with the underlying evidence to support them, are presented in conjunction with current treatment recommendations. Both AREDS and AREDS2 are discussed, as are avenues for further research, including supplementation with vitamin D and saffron. Despite the considerable disease burden of atrophic AMD, few effective therapies are available to treat it, and further research is required.

引用

页码：448 / 462

页数：15

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