Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity

被引：55

作者：

Lorenzon, Esteban N. ^{[1
]}

Piccoli, Julia P. ^{[2
]}

Santos-Filho, Norival A. ^{[3
]}

Cilli, Eduardo M. ^{[2
]}

机构：

[1] Univ Fed Jatai, Unidade Acad Especial Saude, Jatai, GO, Brazil

[2] UNESP Univ Estadual Paulista, Inst Quim, Araraquara, SP, Brazil

[3] UNESP Univ Estadual Paulista, Campus Expt Registro, Registro, SP, Brazil

来源：

PROTEIN AND PEPTIDE LETTERS | 2019年 / 26卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Peptide; antimicrobial; dimerization; mechanism of action; membrane; Antimicrobial Peptides (AMPs); MEMBRANE INTERACTIONS; MAGAININ; 2; ANTIBACTERIAL PEPTIDES; BIOLOGICAL-ACTIVITIES; MECHANISM; ANALOGS; BACTERIAL; DESIGN; DIMER; PERMEABILIZATION;

D O I：

10.2174/0929866526666190102125304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial resistance is a global health problem with strong social and economic impacts. The development of new antimicrobial agents is considered an urgent challenge. In this regard, Antimicrobial Peptides (AMPs) appear to he novel candidates to overcome this problem. The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although the exact mechanism of action of AMPs remains controversial, most AMPs act through membrane disruption of the target cell. Several strategies have been used to improve AMP activity-, such as peptide dimerization. In this review, we focus on AMP dimerization, showing many examples of dimerized peptides and their effects on biological activity. Although more studies are necessary to elucidate the relationship between peptide properties and the dimerization effect on antimicrobial activity, dimerization constitutes a promising strategy to improve the effectiveness of AMPs.

引用

页码：98 / 107

页数：10

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