Regulation of B cell fates by BCR signaling components

被引：90

作者：

Kurosaki, T ^{[1
]}

机构：

[1] Kansai Med Univ, Inst Liver Res, Dept Mol Genet, Moriguchi, Osaka 5708506, Japan

[2] RIKEN, Lab Lymphocyte Differentiat, Res Ctr Allergy & Immunol, Moriguchi, Osaka 5708506, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(02)00344-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent results obtained in mice harboring cytoplasmic mutations of Igalpha and/or Igbeta have reinforced the concept that the strength of BCR signaling is important for ensuring appropriate developmental outcomes as well as antigen-specific responses. To establish the optimal signaling intensity and duration, the BCR utilizes positive and negative regulatory molecules. Studies are beginning to reveal how these molecules maintain immunological homeostasis and tolerance.

引用

页码：341 / 347

页数：7

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