Osteoimmunology - The hidden immune regulation of bone

被引：112
作者：
Caetano-Lopes, J. [1 ]
Canhao, H. [1 ,2 ]
Fonseca, J. E. [1 ,2 ]
机构：
[1] Univ Lisbon, Rheumatol Res Unit, Inst Mol Med, Fac Med, P-1649028 Lisbon, Portugal
[2] Hosp Santa Maria, Rheumatol & Metab Bone Dis Dept, Lisbon, Portugal
来源：
AUTOIMMUNITY REVIEWS | 2009年 / 8卷 / 03期
关键词：
Osteoimmunology; Osteoimmunoendocrinology; Bone; Immune system; Adipose tissue; PPAR-GAMMA; MOLECULAR-MECHANISMS; T-CELLS; METABOLISM; DIFFERENTIATION; INFLAMMATION; INHIBIT; INNATE; LEPTIN; OSTEOCLASTOGENESIS;
D O I：
10.1016/j.autrev.2008.07.038
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Osteoimmunology is an emerging field of research dedicated to the investigation of the interactions between the immune and skeletal systems. These interactions are not only mediated by the release of cytokines and chemokines but also by direct cell-cell contact. Recently, it was proposed that immunoreceptors found in the immune cells are also an essential signal for osteoclasts activation, along with receptor activator NF-kappa B (RANK) ligand (RANKL) and macrophage-colony stimulating factor (M-CSF). In addition, adipose tissue also produces several factors (adipokines) that are known to interfere with the immune system and bone homeostasis. Chronic inflammation strongly influences osteoimmunology determining profound metabolic, structural and functional changes in bone. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：250 / 255
页数：6
相关论文
共 38 条
[1]   Osteoimmunology - Bone versus immune system [J].
Arron, JR ;
Choi, Y .
NATURE, 2000, 408 (6812) :535-536
[2]   The molecular understanding of osteoclast differentiation [J].
Asagiri, Masataka ;
Takayanagi, Hiroshi .
BONE, 2007, 40 (02) :251-264
[3]   Mechanisms of T regulatory cell function [J].
Askenasy, Nadir ;
Kaminitz, Ayelet ;
Yarkoni, Shai .
AUTOIMMUNITY REVIEWS, 2008, 7 (05) :370-375
[4]   Taking a Toll on the bones: Regulation of bone metabolism by innate immune regulators [J].
Bar-Shavit, Zvi .
AUTOIMMUNITY, 2008, 41 (03) :195-203
[5]   The role of leptin in innate and adaptive immune responses [J].
Bernotiene, Eiva ;
Palmer, Gaby ;
Gabay, Cem .
ARTHRITIS RESEARCH & THERAPY, 2006, 8 (05)
[6]  
Caetano-Lopes J, 2007, ACTA REUMATOL PORT, V32, P103
[7]   The cell biology of bone metabolism [J].
Datta, H. K. ;
Ng, W. F. ;
Walker, J. A. ;
Tuck, S. P. ;
Varanasi, S. S. .
JOURNAL OF CLINICAL PATHOLOGY, 2008, 61 (05) :577-587
[8]   Osteoimmunology: A view from the bone [J].
David, Jean-Pierre .
ADVANCES IN IMMUNOLOGY, VOL 95, 2007, 95 :149-165
[9]   Osteoclast receptors and signaling [J].
Del Fattore, Andrea ;
Teti, Anna ;
Rucci, Nadia .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2008, 473 (02) :147-160
[10]  
Fonseca JE, 2005, CLIN EXP RHEUMATOL, V23, P185
1234