ESC guidelines 2015 pulmonary hypertension: diagnosis and treatment

被引:24
作者
Opitz, Christian [1 ]
Rosenkranz, Stephan [2 ]
Ghofrani, Hossein Ardeschir [3 ]
Gruenig, Ekkehard [4 ]
Klose, Hans [5 ]
Olschewski, Horst [6 ]
Hoeper, Marius [7 ]
机构
[1] DRK Kliniken Berlin Westend, Innere Med Klin, Schwerpunkt Kardiol, Berlin, Germany
[2] Univ Cologne, Herzzentrum, Klin Innere Med 3, Cologne, Germany
[3] Univ Giessen Klinikum, Schwerpunkt Pneumol, Med Klin & Poliklin 2, Giessen, Germany
[4] Univ Klinikum Heidelberg, Zentrums PH, Thoraxklin, Heidelberg, Germany
[5] Univ Klinikums Hamburg Eppendorf, Med Klin & Poliklin 2, Sekt Pneumol, Hamburg, Germany
[6] Univ Klin Innere Med, Klin Abt Pulmonol, Graz, Austria
[7] Hannover Med Sch, Klin Pneumol, Zentrum Innere Med, Hannover, Germany
关键词
ARTERIAL-HYPERTENSION; HEART-FAILURE; RIOCIGUAT; TRIAL;
D O I
10.1055/s-0042-117784
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pulmonary hypertension (PH) is characterized by an increase in PAPmean > 25 mmHg associated with a reduced life expectancy. Recent advances in the management of these patients provided the basis for the updated recommendations of the 2015 joint guidelines of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) on the diagnosis and treatment of pulmonary hypertension. The updated version includes important modifications with regards to hemodynamic definitions, clinical classification and diagnostic assessment of patients with PH. In addition, risk stratification and PH treatment were profoundly modified, introducing novel drugs and improved treatment strategies such as early combination therapy. Finally, the new ESC /ERS guidelines provide formal recommendations for the management of PH due to left heart or chronic lung disease and chronic thromboembolic pulmonary hypertension, and define criteria for specialized PH expert centers. © 2016 Georg Thieme Verlag KG, Stuttgart, New York.
引用
收藏
页码:1764 / 1769
页数:6
相关论文
共 13 条
[1]   Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial [J].
Abraham, William T. ;
Stevenson, Lynne W. ;
Bourge, Robert C. ;
Lindenfeld, Jo Ann ;
Bauman, Jordan G. ;
Adamson, Philip B. .
LANCET, 2016, 387 (10017) :453-461
[2]   Acute Hemodynamic Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Diastolic Heart Failure (DILATE-1) [J].
Bonderman, Diana ;
Pretsch, Ingrid ;
Steringer-Mascherbauer, Regina ;
Jansa, Pavel ;
Rosenkranz, Stephan ;
Tufaro, Caroline ;
Bojic, Andja ;
Lam, Carolyn S. P. ;
Frey, Reiner ;
Kilama, Michael Ochan ;
Unger, Sigrun ;
Roessig, Lothar ;
Lang, Irene M. .
CHEST, 2014, 146 (05) :1274-1285
[3]   Riociguat for Patients With Pulmonary Hypertension Caused by Systolic Left Ventricular Dysfunction A Phase IIb Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Hemodynamic Study [J].
Bonderman, Diana ;
Ghio, Stefano ;
Felix, Stephan B. ;
Ghofrani, Hossein-Ardeschir ;
Michelakis, Evangelos ;
Mitrovic, Veselin ;
Oudiz, Ronald J. ;
Boateng, Francis ;
Scalise, Andrea-Viviana ;
Roessig, Lothar ;
Semigran, Marc J. .
CIRCULATION, 2013, 128 (05) :502-U95
[4]   Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension [J].
Galie, N. ;
Barbera, J. A. ;
Frost, A. E. ;
Ghofrani, H-A. ;
Hoeper, M. M. ;
McLaughlin, V. V. ;
Peacock, A. J. ;
Simonneau, G. ;
Vachiery, J-L. ;
Gruenig, E. ;
Oudiz, R. J. ;
Vonk-Noordegraaf, A. ;
White, R. J. ;
Blair, C. ;
Gillies, H. ;
Miller, K. L. ;
Harris, J. H. N. ;
Langley, J. ;
Rubin, L. J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (09) :834-844
[5]   2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT) [J].
Galie, Nazzareno ;
Humbert, Marc ;
Vachiery, Jean-Luc ;
Gibbs, Simon ;
Lang, Irene ;
Torbicki, Adam ;
Simonneau, Gerald ;
Peacock, Andrew ;
Noordegraaf, Anton Vonk ;
Beghetti, Maurice ;
Ghofrani, Ardeschir ;
Gomez Sanchez, Miguel Angel ;
Hansmann, Georg ;
Klepetko, Walter ;
Lancellotti, Patrizio ;
Matucci, Marco ;
McDonagh, Theresa ;
Pierard, Luc A. ;
Trindade, Pedro T. ;
Zompatori, Maurizio ;
Hoeper, Marius .
EUROPEAN HEART JOURNAL, 2016, 37 (01) :67-+
[6]   Riociguat for the Treatment of Pulmonary Arterial Hypertension [J].
Ghofrani, Hossein-Ardeschir ;
Galie, Nazzareno ;
Grimminger, Friedrich ;
Gruenig, Ekkehard ;
Humbert, Marc ;
Jing, Zhi-Cheng ;
Keogh, Anne M. ;
Langleben, David ;
Kilama, Michael Ochan ;
Fritsch, Arno ;
Neuser, Dieter ;
Rubin, Lewis J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :330-340
[7]   A global view of pulmonary hypertension [J].
Hoeper, Marius M. ;
Humbert, Marc ;
Souza, Rogerio ;
Idrees, Majdy ;
Kawut, Steven M. ;
Sliwa-Hahnle, Karen ;
Jing, Zhi-Cheng ;
Gibbs, J. Simon R. .
LANCET RESPIRATORY MEDICINE, 2016, 4 (04) :306-322
[8]   Pre-Capillary, Combined, and Post-Capillary Pulmonary Hypertension A Pathophysiological Continuum [J].
Opitz, Christian F. ;
Hoeper, Marius M. ;
Gibbs, J. Simon R. ;
Kaemmerer, Harald ;
Pepke-Zaba, Joanna ;
Coghlan, J. Gerry ;
Scelsi, Laura ;
D'Alto, Michele ;
Olsson, Karen M. ;
Ulrich, Silvia ;
Scholtz, Werner ;
Schulz, Uwe ;
Gruenig, Ekkehard ;
Vizza, Carmine D. ;
Staehler, Gerd ;
Bruch, Leonhard ;
Huscher, Doerte ;
Pittrow, David ;
Rosenkranz, Stephan .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (04) :368-378
[9]   Macitentan and Morbidity and Mortality in Pulmonary Arterial Hypertension [J].
Pulido, Tomas ;
Adzerikho, Igor ;
Channick, Richard N. ;
Delcroix, Marion ;
Galie, Nazzareno ;
Ghofrani, Hossein-Ardeschir ;
Jansa, Pavel ;
Jing, Zhi-Cheng ;
Le Brun, Franck-Olivier ;
Mehta, Sanjay ;
Mittelholzer, Camilla M. ;
Perchenet, Loic ;
Sastry, B. K. S. ;
Sitbon, Olivier ;
Souza, Rogerio ;
Torbicki, Adam ;
Zeng, Xiaofeng ;
Rubin, Lewis J. ;
Simonneau, Gerald .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (09) :809-818
[10]   Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial [J].
Redfield, Margaret M. ;
Chen, Horng H. ;
Borlaug, Barry A. ;
Semigran, Marc J. ;
Lee, Kerry L. ;
Lewis, Gregory ;
LeWinter, Martin M. ;
Rouleau, Jean L. ;
Bull, David A. ;
Mann, Douglas L. ;
Deswal, Anita ;
Stevenson, Lynne W. ;
Givertz, Michael M. ;
Ofili, Elizabeth O. ;
O'Connor, Christopher M. ;
Felker, G. Michael ;
Goldsmith, Steven R. ;
Bart, Bradley A. ;
McNulty, Steven E. ;
Ibarra, Jenny C. ;
Lin, Grace ;
Oh, Jae K. ;
Patel, Manesh R. ;
Kim, Raymond J. ;
Tracy, Russell P. ;
Velazquez, Eric J. ;
Anstrom, Kevin J. ;
Hernandez, Adrian F. ;
Mascette, Alice M. ;
Braunwald, Eugene .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (12) :1268-1277