The use of mass spectrometry to improve the diagnosis and the management of the HPA axis

被引：24
作者：
Monaghan, Phillip J. [1 ]
Keevil, Brian G. [2 ]
Trainer, Peter J. [3 ]
机构：
[1] Christie NHS Fdn Trust, Dept Clin Biochem, Manchester M20 4BX, Lancs, England
[2] Univ S Manchester Hosp, Dept Clin Biochem, Manchester M23 9LT, Lancs, England
[3] Christie NHS Fdn Trust, Dept Endocrinol, Manchester M20 4BX, Lancs, England
来源：
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2013年 / 14卷 / 02期
关键词：
HPA axis; LC-MS/MS; Immunoassay; Cortisol; Cortisone; Cushing's syndrome; NIGHT SALIVARY CORTISOL; PLASMA-RENIN ACTIVITY; 11-BETA-HYDROXYLASE INHIBITOR METYRAPONE; CORTICOSTEROID-BINDING GLOBULIN; CONGENITAL ADRENAL-HYPERPLASIA; CLINICAL-PRACTICE GUIDELINE; SOLID-PHASE EXTRACTION; URINARY FREE CORTISOL; SERUM-FREE CORTISOL; LIQUID-CHROMATOGRAPHY;
D O I：
10.1007/s11154-013-9240-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is becoming a standard analytical tool in the clinical laboratory for the measurement of small molecules, including steroid hormones. Endocrinologists are coming to acknowledge the superior quality of measurement that is achievable by LC-MS/MS through the enhanced analytical specificity and high sensitivity that this technique offers over conventional immunoassay (IA) methodologies. Additionally, LC-MS/MS overcomes many of the problems encountered in immunoassays, such as anti-reagent antibody interferences and cross-reactivity with structurally related compounds. The potential benefits of applying LC-MS/MS for the assessment of the hypothalamic-pituitary-adrenal (HPA) axis are beginning to be realised. This review critically evaluates recent developments in the application of LC-MS/MS for measurement of glucocorticoids and mineralocorticoids towards the diagnosis and management of HPA axis disorders and aims to address the current unmet need in this expanding field of endocrinology for which future studies into the potential applications of LC-MS/MS should be directed.
引用
收藏
页码：143 / 157
页数：15
相关论文
共 88 条
[61]   BIOMARKERS Salivary cortisol or cortisone? [J].
Raff, Hershel ;
Findling, James W. .
NATURE REVIEWS ENDOCRINOLOGY, 2010, 6 (12) :658-660
[62]   Utility of Salivary Cortisol Measurements in Cushing's Syndrome and Adrenal Insufficiency [J].
Raff, Hershel .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (10) :3647-3655
[63]   Simultaneous measurements of urinary free cortisol and cortisone for the assessment of functional glucocorticoid activity [J].
Remer, Thomas ;
Maser-Gluth, Christiane .
CLINICAL CHEMISTRY, 2007, 53 (10) :1870-1871
[64]   Advantage of salivary cortisol measurements in the diagnosis of glucocorticoid related disorders [J].
Restituto, P. ;
Galofre, J. C. ;
Gil, M. J. ;
Mugueta, C. ;
Santos, S. ;
Monreal, J. I. ;
Varo, N. .
CLINICAL BIOCHEMISTRY, 2008, 41 (09) :688-692
[65]   Automated chemiluminescence-immunoassay for aldosterone during dynamic testing: Comparison to radioimmunoassays with and without extraction steps [J].
Schirpenbach, Caroline ;
Seiler, Lysann ;
Maser-Gluth, Christiane ;
Beuschlein, Felix ;
Reincke, Martin ;
Bidlingmaier, Martin .
CLINICAL CHEMISTRY, 2006, 52 (09) :1749-1755
[66]   The cortisol response to awakening in relation to different challenge tests and a 12-hour cortisol rhythm [J].
Schmidt-Reinwald, A ;
Pruessner, JC ;
Hellhammer, DH ;
Federenko, I ;
Rohleder, N ;
Schürmeyer, TH ;
Kirschbaum, C .
LIFE SCIENCES, 1999, 64 (18) :1653-1660
[67]   Management of patients with adrenal cancer: recommendations of an international consensus conference [J].
Schteingart, DE ;
Doherty, GM ;
Gauger, PG ;
Giordano, TJ ;
Hammer, GD ;
Korobkin, M ;
Worden, FP .
ENDOCRINE-RELATED CANCER, 2005, 12 (03) :667-680
[68]   Plasma Renin Activity Enzyme-Kinetic Assay: Protection of Angiotensin I from Bacterial Degradation [J].
Sealey, Jean E. ;
Laragh, John H. .
CLINICAL CHEMISTRY, 2011, 57 (03) :529-530
[69]  
Siemens Healthcare Diagnostics Inc, 2011, ADVIA CENT XP IMM SY
[70]   Analytical error and interference in immunoassay: minimizing risk [J].
Sturgeon, Catharine M. ;
Viljoen, Adie .
ANNALS OF CLINICAL BIOCHEMISTRY, 2011, 48 :418-432
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