Risk of Major Osteoporotic Fracture After Cardiovascular Disease: A Population-Based Cohort Study in Taiwan

被引：32

作者：

Lai, Shih-Wei ^{[1
,2
]}

Liao, Kuan-Fu ^{[3
,4
,5
]}

Lai, Hsueh-Chou ^{[6
,7
]}

Tsai, Pang-Yao ^{[8
,9
]}

Lin, Cheng-Li ^{[8
,9
]}

Chen, Pei-Chun ^{[10
]}

Sung, Fung-Chang ^{[8
,9
]}

机构：

[1] China Med Univ, Sch Med, Taichung 404, Taiwan

[2] China Med Univ Hosp, Dept Family Med, Taichung, Taiwan

[3] China Med Univ, Grad Inst Integrated Med, Taichung 404, Taiwan

[4] Taichung Tzu Chi Gen Hosp, Dept Internal Med, Taichung, Taiwan

[5] Cent Taiwan Univ Sci & Technol, Dept Hlth Care Adm, Taichung, Taiwan

[6] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan

[7] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan

[8] China Med Univ, Dept Publ Hlth, Taichung 404, Taiwan

[9] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[10] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan

来源：

JOURNAL OF EPIDEMIOLOGY | 2013年 / 23卷 / 02期

关键词：

atherosclerosis; cardiovascular disease; cerebrovascular disease; fracture; heart failure; HIP FRACTURE; OLDER-PEOPLE; POLYPHARMACY; ASSOCIATION; WOMEN; CANCER; BURDEN;

D O I：

10.2188/jea.JE20120071

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: We investigated the association between cardiovascular disease (CVD) and the risk of major osteoporotic fracture in Taiwan. Methods: Using the Taiwan National Health Insurance Database for the period 2000-2007, we classified 43 874 patients aged 50 years or older with newly diagnosed CVD (coronary artery disease, heart failure, cerebrovascular disease, or peripheral atherosclerosis) as the CVD group and 43 874 subjects without CVD (frequency-matched by sex, age, and date selected) as the non-CVD group. Incidence and hazard ratios (HRs) for major osteoporotic fracture of the spine, hip, humerus, and forearm/wrist were estimated for the period until the end of 2010. Results: After adjustment for confounders, the overall BRs for major osteoporotic fracture were 1.24 (95% CI = 1.13, 1.36) in men with CVD and 1.18 (95% CI = 1.11, 1.25) in women with CVD, as compared with the non-CVD group. As compared with the non-CVD group, the adjusted BR for major osteoporotic fracture was highest among subjects with cerebrovascular disease (HR 1.31; 95% CI 1.23, 1.39), followed by those with heart failure (HR 1.18; 95% CI 1.11, 1.27), peripheral atherosclerosis (HR 1.12; 95% CI 1.04, 1.20), and coronary artery disease (HR 1.07; 95% CI 1.01, 1.12). Conclusions: CVD is associated with risk of major osteoporotic fracture in men and women in Taiwan.

引用

页码：109 / 114

页数：6

共 16 条

[1] Women with Cardiovascular Disease Have Increased Risk of Osteoporotic Fracture [J].