Fluorine-containing taxoid anticancer agents and their tumor-targeted drug delivery

被引:24
作者
Seitz, Joshua [1 ]
Vineberg, Jacob G. [1 ]
Zuniga, Edison S. [1 ]
Ojima, Iwao [1 ,2 ]
机构
[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA
基金
美国国家卫生研究院;
关键词
Tumor-targeted; Drug delivery system; Anticancer agents; Taxoid; Fluorescent probe; Fluorine probe; ALBUMIN-BOUND PACLITAXEL; NEW-GENERATION TAXOIDS; CARBON NANOTUBES; DOCETAXEL TAXOTERE(R); BIOLOGICAL EVALUATION; LIVER-MICROSOMES; FATTY-ACIDS; IN-VITRO; CANCER; CELLS;
D O I
10.1016/j.jfluchem.2013.05.013
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A long-standing problem of conventional chemotherapy is the lack of tumor-specific treatments. Traditional chemotherapy relies on the premise that rapidly proliferating cancer cells are more likely to be killed by a cytotoxic agent. In reality, however, cytotoxic agents have very little or no specificity, which leads to systemic toxicity, causing undesirable severe side effects. Consequently, various "molecularly targeted cancer therapies" have been developed for use in specific cancers, including tumor-targeted drug delivery systems. In general, such a drug delivery system consists of a tumor recognition moiety and a cytotoxic "warhead" connected through a "smart" linker to form a conjugate. When a multi-functionalized nanomaterial is used as the vehicle, a "Trojan Horse" approach can be used for mass delivery of cytotoxic "warheads" to maximize the efficacy. Exploitation of the special properties of fluorine has proven successful in the development of new and effective biochemical tools as well as therapeutic agents. Fluorinated congeners can also serve as excellent probes for the investigation of biochemical mechanisms. F-19 NMR can provide unique and powerful tools for mechanistic investigations in chemical biology. This account presents our recent progress, in perspective, on the molecular approaches to the design and development of novel tumor-targeted drug delivery systems for new generation chemotherapy by exploiting the unique nature of fluorine. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:157 / 165
页数:9
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