Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors

被引：139
作者：
Zhao, Rongbao
Goldman, I. David [1 ,2 ]
机构：
[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 2-3期
基金：
瑞士国家科学基金会;
关键词：
SCL19A1; SLC19A2; SLC19A3; SCL46A1; Folate; Thiamine; Hereditary folate malabsorption; Thiamine-responsive megaloblastic anemia; Folate receptor; BASAL GANGLIA DISEASE; HELA-CELLS LACKING; HUMAN SOLID TUMORS; MEMBRANE-TRANSPORT; METHOTREXATE TRANSPORT; BINDING-PROTEIN; FUNCTIONAL-CHARACTERIZATION; PHARMACOLOGICAL-ACTIVITY; CELLULAR-LOCALIZATION; ANTIFOLATE INHIBITORS;
D O I：
10.1016/j.mam.2012.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease). (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：373 / 385
页数：13
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