Stoppage in Autism Spectrum Disorders

被引：11

作者：

Gronborg, Therese K. ^{[1
]}

Hansen, Stefan N. ^{[1
]}

Nielsen, Svend V. ^{[2
]}

Skytthe, Axel ^{[3
]}

Parner, Erik T. ^{[1
]}

机构：

[1] Aarhus Univ, Dept Publ Hlth, Biostat Sect, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Dept Math, DK-8000 Aarhus C, Denmark

[3] Univ Southern Denmark, Inst Publ Hlth, Danish Twin Registry, Epidemiol Biostat & Biodemog, Odense, Denmark

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2015年 / 45卷 / 11期

关键词：

Autism spectrum disorder; Sibling recurrence risk; Stoppage; SIBLING RECURRENCE; TWIN PAIRS; RISK; EPIDEMIOLOGY; CONCORDANCE; ETIOLOGY; GENETICS; REGISTRY; COHORT; TRENDS;

D O I：

10.1007/s10803-015-2497-3

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Stoppage refers to changes in reproductive behavior following the birth of a child with a severe disease. The presence of stoppage can bias estimates of sibling recurrence risk if not properly addressed. If stoppage occurs non-randomly (differential stoppage), it is possibly an additional source of bias in sibling recurrence risk estimation. This study investigated whether stoppage occurs in Danish families with a firstborn child diagnosed with autism spectrum disorders, and if stoppage was differential. We found that stoppage occurs moderately in Danish families affected by autism spectrum disorders, and that stoppage is differential. However, differential stoppage is a minor source of estimation bias in Danish sibling recurrence risk studies of autism spectrum disorders.

引用

页码：3509 / 3519

页数：11

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