Pharmacokinetics and bioavailability of cefquinome in healthy piglets

被引:54
作者
Li, X. B. [1 ,2 ]
Wu, W. X. [1 ]
Su, D. [1 ]
Wang, Z. J. [1 ]
Jiang, H. Y. [1 ]
Shen, J. Z. [1 ]
机构
[1] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
[2] Chinese Acad Agr Sci, Feed Res Inst, Beijing, Peoples R China
关键词
D O I
10.1111/j.1365-2885.2008.00989.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A study on bioavailability and pharmacokinetics of cefquinome in piglets was conducted after intravenous (i.v.) and intramuscular (i.m.) administrations of 2.0 mg/kg of body weight, respectively. Plasma concentrations were measured by high-performance liquid chromatography assay with UV detector at 268-nm wavelength. Plasma concentration-time data after i.v. administration were best fit by a two-compartment model. The pharmacokinetic values were distribution half-life 0.27 +/- 0.21 h, elimination half-life 1.85 +/- 1.11 h, total body clearance 0.26 +/- 0.08 L/kg.h, area under curve 8.07 +/- 1.91 mu g.h/mL and volume of distribution at steady state 0.46 +/- 0.10 L/kg. Plasma concentration-time data after i.m. administration were also best fit by a two-compartment model. The pharmacokinetic parameters were distribution half-life 0.88 +/- 0.42 h, elimination half-life 4.36 +/- 2.35 h, peak concentration 4.01 +/- 0.57 mu g/mL and bioavailability 95.13 +/- 9.93%.
引用
收藏
页码:523 / 527
页数:5
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