Reduction of Anthelmintic Drug (Methyl [1]carbamate-albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

被引：1

作者：

Kamau, Geoffrey N. ^{[1
]}

Mazzochette, Zahilis ^{[2
]}

Kahi, Helen K. ^{[1
]}

Mugweru, Amos ^{[2
]}

机构：

[1] Univ Nairobi, Dept Chem, Sch Phys Sci, Coll Biol & Phys Sci, POB 30197-00100, Nairobi, Kenya

[2] Rowan Univ, Dept Biochem & Chem, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA

来源：

ELECTROANALYSIS | 2016年 / 28卷 / 11期

关键词：

Albendazole; Gold electrode; Electrochemical Reduction; LC-MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; ALBENDAZOLE SULFOXIDE; IN-VITRO; METABOLISM; ABSORPTION; ASSAY; FENBENDAZOLE; DISSOLUTION; CYSTICERCI;

D O I：

10.1002/elan.201600140

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Albendazole (ABZ) is a widely used anthelmintic drug for the treatment of parasitic worms and other diseases. The bulk electrolysis reduction reaction of albendazole (ABZ) was carried out in ammonium bromide-acetonitrile solution under stirring conditions. The reduction of albendazole at gold electrode gave three non-reversible waves. The average value of the electron transfer coefficient (n) was found to be 0.505. The measured diffusion coefficient (D) had a value of 0.143x10(-8)cm(2)s(-1). The bulk electrochemical reduction of ABZ products were characterized using liquid chromatography-mass spectroscopy. Three cyclic voltammetry reduction waves were observed using a gold electrode and three chromatographic peaks were observed using liquid chromatography- Mass spectrometry. The observed results suggested that the second and third reduction steps occurred at the sulfur functional group of albendazole.

引用

页码：2697 / 2702

页数：6

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