Cell Therapies for IBD: What Works?

被引：11

作者：

Ricart, Elena ^{[1
]}

Jauregui-Amezaga, Aranzazu ^{[1
]}

Ordas, Ingrid ^{[1
]}

Pino, Susana ^{[1
]}

Ramirez, Anna M. ^{[1
]}

Panes, Julian ^{[1
]}

机构：

[1] CIBER EHD Hosp Clin, Dept Gastroenterol, Barcelona, Spain

来源：

CURRENT DRUG TARGETS | 2013年 / 14卷 / 12期

关键词：

Bone marrow transplantation; Crohn's disease; cell therapy; haematopoietic stem cells; inflammatory bowel disease; mesenchymal stem cells; Treg cells; ulcerative colitis; MESENCHYMAL STEM-CELLS; REGULATORY T-CELLS; REFRACTORY CROHNS-DISEASE; INFLAMMATORY-BOWEL-DISEASE; HIGH-DOSE CYCLOPHOSPHAMIDE; VERSUS-HOST-DISEASE; TERM-FOLLOW-UP; BONE-MARROW; AUTOIMMUNE-DISEASES; ADIPOSE-TISSUE;

D O I：

10.2174/13894501113146660234

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inflammatory response in patients with inflammatory bowel disease is a complex self-amplifying process with multiple cellular and molecular pathways controlling activation and shut-off of the process. Available therapeutic interventions with drugs that have a very selective action, such as anti-tumor necrosis factor antibodies, or broader effects such as corticosteroids still leave a significant proportion of patients with Crohn's disease and ulcerative colitis insufficiently treated. Cellular therapies are emerging as promising new approaches to treat inflammatory bowel diseases and in particular Crohn's disease. Experimental and clinical data are the origin of the increasing utilization of cell therapies for severe immune-mediated diseases including inflammatory bowel disease. The types of cell therapies for these diseases can be divided into two different areas: hematopoietic stem cell therapies, and selected/conditioned immune cell therapy, the latter including mesenchymal stem cells and T-regulatory cells-based therapies.

引用

页码：1453 / 1459

页数：7

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