Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus

被引：65

作者：

Xia, Y

Fan, ZJ

Yao, JH

Liao, Q

Li, W

Qu, FQ

Peng, L ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China

[2] Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Dept Comp Chem & Chemoinformat, Shanghai 200032, Peoples R China

[4] CNRS, UMR 6114, Dept Chim, F-13288 Marseille, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 10期

基金：

中国国家自然科学基金;

关键词：

triazoles; antiviral candidates; bitriazolyl compounds; Huispen; 1.3-cyclcoaddition; tobacco mosaic virus;

D O I：

10.1016/j.bmcl.2006.02.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bitriazolyl compounds were synthesized and their activity against tobacco mosaic virus was assessed. Two of them showed promising antiviral activity and were more potent than the reference compounds. Moreover, these compounds are predicted not to be carcinogenic or mutagenic based on the prediction systems. Therefore, the bitriazolyl compounds may provide interesting new leads or scaffolds for use in further attempts to screen novel antiviral candidates. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2693 / 2698

页数：6

共 17 条

[1] Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus [J].