In Vivo Whole Animal Fluorescence Imaging of a Microparticle-Based Oral Vaccine Containing (CuInSexS2-x)/ZnS Core/Shell Quantum Dots

被引：90
作者：
Panthani, Matthew G.
Khan, Tarik A.
Reid, Dariya K.
Hellebusch, Daniel J.
Rasch, Michael R.
Maynard, Jennifer A. [1 ]
Korgel, Brian A.
机构：
[1] Univ Texas Austin, Dept Chem Engn, Texas Mat Inst, Austin, TX 78712 USA
来源：
NANO LETTERS | 2013年 / 13卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Quantum dots; CuInSe2; CuInS2; near-infrared; in vivo imaging; bioimaging; photoluminescence; M-CELLS; YERSINIA-PSEUDOTUBERCULOSIS; OPTICAL-PROPERTIES; LYMPHOID-TISSUE; NANOCRYSTALS; CUINSE2; PHOTOVOLTAICS; NANOPARTICLES; LUMINESCENT; MICE;
D O I：
10.1021/nl402054w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
引用
收藏
页码：4294 / 4298
页数：5
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