Investigation of the physical-mechanical properties of Eudragit® RS PO/RL PO and their mixtures with common pharmaceutical excipients

被引:19
作者
Dave, Vivek S. [1 ]
Fahmy, Raafat M. [2 ]
Hoag, Stephen W. [3 ]
机构
[1] St John Fisher Coll, Wegmans Sch Pharm, Rochester, NY 14618 USA
[2] Ctr Vet Med, Off New Anim Drug Evaluat, Rockville, MD 20855 USA
[3] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
关键词
Heckel analysis; strain rate sensitivity; tabletability; compressibility; compactibility; work of compaction; elastic recovery index; ACRYLIC RESIN POLYMERS; COMPRESSION BEHAVIOR; TENSILE-STRENGTH; COMPACTION PROPERTIES; TABLETING PROPERTIES; ELASTIC RECOVERY; PUNCH VELOCITY; HECKEL; DEFORMATION; SPEED;
D O I
10.3109/03639045.2012.714786
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Ammonio methacrylate copolymers Eudragit (R) RS PO and Eudragit (R) RL PO have found widespread use as key components in various types of extended release solid dosage forms. The deformation behavior of neat polymers and binary mixes was evaluated using Heckel Analysis, strain rate sensitivity, work of compaction and elastic recovery index. Additionally, the compact forming ability of neat materials and binary mixes were evaluated by analyzing their tabletability, compressibility and compactibility profiles. The Heckel analysis of both polymers exhibited a speed-sensitive deformation behavior typical to plastic materials. The yield values of the binary mixes of the polymers with microcrystalline cellulose revealed a linear relationship with the weight fractions of individual components. The yield values of binary mixes of both the polymers with dibasic calcium phosphate exhibited slight negative deviations from linearity. Both polymers exhibited axial relaxation after ejection typical of viscoelastic materials, as measured by the elastic recovery index values. The work of compaction and the elastic recovery index values of the binary mixtures were found to be linearly related to the weight fractions of the individual components thus, confirming ideal mixing behavior based on the composition. Addition of microcrystalline cellulose to both polymers significantly improved their tabletability and compactibility. The tensile strengths of the compacts prepared with neat materials and binary mixes with microcrystalline cellulose, dibasic calcium phosphate and lactose were the function of their solid fraction and independent of the tableting speeds tested; thus, validating compactibility as a reliable parameter in predicting acceptable tablet properties.
引用
收藏
页码:1113 / 1125
页数:13
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