Rapid increase of serum neuron specific enolase level and tachyphylaxis of EGFR-tyrosine kinase inhibitor indicate small cell lung cancer transformation from EGFR positive lung adenocarcinoma?

被引：59

作者：

Zhang, Yan ^{[1
]}

Li, Xiao-Yu ^{[1
]}

Tang, Yuan ^{[2
]}

Xu, Yong ^{[1
]}

Guo, Wen-Hao ^{[1
]}

Li, Yan-Chu ^{[1
]}

Liu, Xiao-Ke ^{[1
]}

Huang, Chu-Ying ^{[1
]}

Wang, Yong-Sheng ^{[1
]}

Wei, Yu-Quan ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, West China Med Sch, Ctr Canc,Dept Thoracic Oncol,State Key Lab Biothe, Chengdu 610064, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610064, Sichuan, Peoples R China

来源：

LUNG CANCER | 2013年 / 81卷 / 02期

关键词：

EGFR mutation; Non-small cell lung cancer; Small cell lung cancer transformation; Neuron specific enolase; CARCINOMA; MUTATIONS;

D O I：

10.1016/j.lungcan.2013.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of an 80-year-old male with relapsed EGFR exon 19 deletion lung adenocarcinoma treated with EGFR-tyrosine kinase inhibitor (TKI), but with poor response and rapid increase of serum neuron specific enolase (NSE). Repeat biopsy identified pathological transformation to small cell lung cancers (SCLC) retaining the same EGFR mutation. This case highlights routine serological testing of NSE may benefit for the lung adenocarcinoma patients resistant to TKIs. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：302 / 305

页数：4

相关论文

共 11 条

[1] Incidence of EGFR Exon 19 Deletions and L858R in Tumor Specimens From Men and Cigarette Smokers With Lung Adenocarcinomas [J].

D'Angelo, Sandra P. ;

Pietanza, M. Catherine ;

Johnson, Melissa L. ;

Riely, Gregory J. ;

Miller, Vincent A. ;

Sima, Camelia S. ;

Zakowski, Maureen F. ;

Rusch, Valerie W. ;

Ladanyi, Marc ;

Kris, Mark G. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15) :2066-2070

[2] Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung [J].

Fukui, Tomoya ;

Tsuta, Koji ;

Furuta, Koh ;

Watanabe, Shun-ichi ;

Asamura, Hisao ;

Ohe, Yuichiro ;

Maeshima, Akiko Miyagi ;

Shibata, Tatsuhiro ;

Masuda, Noriyuki ;

Matsuno, Yoshihiro .

CANCER SCIENCE, 2007, 98 (11) :1714-1719

[3]

Kris MG, 2011, ASCO M, V29

[4] Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation [J].

Morinaga, Ryotaro ;

Okamoto, Isamu ;

Furuta, Kazuyuki ;

Kawano, Yukiko ;

Sekijima, Masaru ;

Dote, Kensaku ;

Satou, Takao ;

Nishio, Kazuto ;

Fukuoka, Masahiro ;

Nakagawa, Kazuhiko .

LUNG CANCER, 2007, 58 (03) :411-413

[5] Transformation to "high grade" neuroendocrine carcinoma as an acquired drug resistance mechanism in EGFR-mutant lung adenocarcinoma [J].

Popat, S. ;

Wotherspoon, A. ;

Nutting, C. M. ;

Gonzalez, D. ;

Nicholson, A. G. ;

O'Brien, M. .

LUNG CANCER, 2013, 80 (01) :1-4

[6] Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors [J].

Sequist, Lecia V. ;

Waltman, Belinda A. ;

Dias-Santagata, Dora ;

Digumarthy, Subba ;

Turke, Alexa B. ;

Fidias, Panos ;

Bergethon, Kristin ;

Shaw, Alice T. ;

Gettinger, Scott ;

Cosper, Arjola K. ;

Akhavanfard, Sara ;

Heist, Rebecca S. ;

Temel, Jennifer ;

Christensen, James G. ;

Wain, John C. ;

Lynch, Thomas J. ;

Vernovsky, Kathy ;

Mark, Eugene J. ;

Lanuti, Michael ;

Iafrate, A. John ;

Mino-Kenudson, Mari ;

Engelman, Jeffrey A. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (75)

[7]

Sun Y, 2011, J CLIN ONCOL, V29, P7522

[8] Epidermal Growth Factor Receptor Mutations in Small Cell Lung Cancer [J].

Tatematsu, Akiko ;

Shimizu, Junichi ;

Murakami, Yoshiko ;

Horio, Yoshitsugu ;

Nakamura, Shigeo ;

Hida, Toyoaki ;

Mitsudomi, Tetsuya ;

Yatabe, Yasushi .

CLINICAL CANCER RESEARCH, 2008, 14 (19) :6092-6096

[9] First Case of Combined Small-Cell Lung Cancer with Adenocarcinoma Harboring EML4-ALK Fusion and an Exon 19 EGFR Mutation in Each Histological Component [J].

Toyokawa, Gouji ;

Taguchi, Kenichi ;

Ohba, Taro ;

Morodomi, Yosuke ;

Takenaka, Tomoyoshi ;

Hirai, Fumihiko ;

Yamaguchi, Masafumi ;

Seto, Takashi ;

Takenoyama, Mitsuhiro ;

Sugio, Kenji ;

Ichinose, Yukito .

JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (12) :E39-E41

[10] A patient with simultaneously appearing adenocarcinoma and small-cell lung carcinoma harbouring an identical EGFR exon 19 mutation [J].

van Riel, S. ;

Thunnissen, E. ;

Heideman, D. ;

Smit, E. F. ;

Biesma, B. .

ANNALS OF ONCOLOGY, 2012, 23 (12) :3188-3189