Targeting T-helper 9 cells and interleukin-9 in autoimmune diseases

被引：60
作者：
Pan, Hai-Feng [1 ,2 ]
Leng, Rui-Xue [1 ,2 ]
Li, Xiang-Pei [3 ]
Zheng, Song Guo [4 ,5 ]
Ye, Dong-Qing [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Peoples R China
[2] Anhui Med Univ, Anhui Prov Lab Populat Hlth & Major Dis Screenin, Hefei, Peoples R China
[3] Anhui Prov Hosp, Dept Rheumatol, Hefei, Peoples R China
[4] Tongji Univ, Shanghai East Hosp, Inst Immunol, Shanghai, Peoples R China
[5] Univ So Calif, Dept Med, Div Rheumatol Immunol, Los Angeles, CA 90089 USA
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2013年 / 24卷 / 06期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
Th9; IL-9; Autoimmune; Therapeutic; SYSTEMIC-LUPUS-ERYTHEMATOSUS; AIRWAY SMOOTH-MUSCLE; TH17; CELLS; MULTIPLE-SCLEROSIS; TGF-BETA; RHEUMATOID-ARTHRITIS; TH9; DENDRITIC CELLS; MAST-CELLS; TREG CELLS;
D O I：
10.1016/j.cytogfr.2013.09.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CD4(+) T helper (Th) cells are central to the modulation of immune responses, with distinct effector subsets defined by their lineage-specific transcription factor expression, cytokines production and immune function. Th9, one of the recently defined subsets of Th cells, are identified by the potent production of interleukin-9 (IL-9). Recent studies have indicated that Th9 cells and IL-9 are closely associated with several autoimmune diseases, such as systemic lupus erythematosus (SLE), experimental autoimmune encephalitis (EAE) and systemic sclerosis (SSc). In the present review, we will briefly discuss the biological features of Th9/IL-9 and summarize recent advances focusing on the role of Th9/IL-9 in the pathogenesis and possible treatment in autoimmune diseases using anti-Th9 (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：515 / 522
页数：8
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