Endocrinologic Diseases in Hemoglobinopathies

被引：0
作者：
El Baba, Khaled
Zantout, Mira S. [1 ]
Azar, Sami T. [1 ]
机构：
[1] Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Endocrinol, Beirut, Lebanon
来源：
ENDOCRINOLOGIST | 2009年 / 19卷 / 01期
关键词：
endocrinologic diseases; hemoglobinopathies; blood transfusion; SICKLE-CELL-DISEASE; BETA-THALASSEMIA MAJOR; IRON CHELATION-THERAPY; BONE-MINERAL DENSITY; GONADAL-FUNCTION; THYROID-FUNCTION; CHILDREN; GROWTH; PREVALENCE; AGE;
D O I：
10.1097/TEN.0b013e318194122e
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite the improvement in chelating therapy, endocrinologic complications are well documented in patients with hemoglobinopathies requiring frequent and recurrent blood transfusion. The most common e findings are delayed puberty and growth failure. Less commonly seen are bone loss, hypothyroidism, and hyperglycemia. In this review, we will explore these complications and discuss management strategies.
引用
收藏
页码：44 / 47
页数：4
相关论文
共 34 条
  • [1] GONADAL FUNCTION ABNORMALITIES IN SICKLE-CELL ANEMIA - STUDIES IN ADULT MALE PATIENTS
    ABBASI, AA
    PRASAD, AS
    ORTEGA, J
    CONGCO, E
    OBERLEAS, D
    [J]. ANNALS OF INTERNAL MEDICINE, 1976, 85 (05) : 601 - 605
  • [2] Ajayi A.A., 2004, Eur J Intern Med, V15, P312, DOI 10.1016/j.ejim.2004.06.003
  • [3] Increased sensitivity to the inhibitory effect of excess iodide on thyroid function in patients with β-thalassemia major and iron overload and the subsequent development of hypothyroidism
    Alexandrides, T
    Georgopoulos, N
    Yarmenitis, S
    Vagenakis, AG
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2000, 143 (03) : 319 - 325
  • [4] Hypoparathyroidism in transfusion-dependent patients with β-thalassemia
    Angelopoulos, NG
    Goula, A
    Rombopoulos, G
    Kaltzidou, V
    Katounda, E
    Kaltsas, D
    Tolis, G
    [J]. JOURNAL OF BONE AND MINERAL METABOLISM, 2006, 24 (02) : 138 - 145
  • [5] HEIGHTS, WEIGHTS, AND SKELETAL AGE OF JAMAICAN ADOLESCENTS WITH SICKLE-CELL ANEMIA
    ASHCROFT, MT
    SERJEANT, GR
    DESAI, P
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 1972, 47 (254) : 519 - &
  • [6] Brinker M R, 1998, Am J Orthop (Belle Mead NJ), V27, P43
  • [7] EFFICACY OF DEFEROXAMINE IN PREVENTING COMPLICATIONS OF IRON OVERLOAD IN PATIENTS WITH THALASSEMIA MAJOR
    BRITTENHAM, GM
    GRIFFITH, PM
    NIENHUIS, AW
    MCLAREN, CE
    YOUNG, NS
    TUCKER, EE
    ALLEN, CJ
    FARRELL, DE
    HARRIS, JW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (09) : 567 - 573
  • [8] EFFECT OF AGE AT THE START OF IRON CHELATION-THERAPY ON GONADAL-FUNCTION IN BETA-THALASSEMIA MAJOR
    BRONSPIEGELWEINTROB, N
    OLIVIERI, NF
    TYLER, B
    ANDREWS, DF
    FREEDMAN, MH
    HOLLAND, FJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (11) : 713 - 719
  • [9] Bone area and bone mineral content deficits in children with sickle cell disease
    Buison, AM
    Kawchak, DA
    Schall, JI
    Ohene-Frempong, K
    Stallings, VA
    Leonard, MB
    Zemel, BS
    [J]. PEDIATRICS, 2005, 116 (04) : 943 - 949
  • [10] Low vitamin D status in children with sickle cell disease
    Buison, AM
    Kawchak, DA
    Schall, J
    Ohene-Frempong, K
    Stallings, VA
    Zemel, BS
    [J]. JOURNAL OF PEDIATRICS, 2004, 145 (05) : 622 - 627
1234