共 44 条
In Vivo Imaging of Bone Using a Deep-Red Fluorescent Molecular Probe Bearing Multiple Iminodiacetate Groups
被引:43
作者:

Harmatys, Kara M.
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Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Cole, Erin L.
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Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Smith, Bradley D.
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h-index: 0
机构:
Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
机构:
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
关键词:
bone targeting;
in vivo imaging;
multivalency;
iminodiacetate;
fluorescence molecular imaging;
squaraine rotaxane;
NONINVASIVE OPTICAL-DETECTION;
7 DIFFERENT FLUOROCHROMES;
DRUG-DELIVERY SYSTEMS;
BISPHOSPHONATE;
AGENTS;
TISSUE;
TETRACYCLINE;
DEPOSITION;
SURFACES;
PEPTIDE;
D O I:
10.1021/mp400357v
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Deep-red fluorescent molecular probes are described that have a dendritic molecular architecture with a squaraine rotaxane core scaffold and multiple peripheral iminodiacetate groups as the bone targeting units. Iminodiacetates have an inherently lower bone affinity than bisphosphonates, and a major goal of the study was to determine how many appended iminodiacetate groups are required for effective deep-red fluorescence imaging of bone in living rodents. A series of in vitro and in vivo imaging studies showed that a tetra(iminodiacetate) probe stains bones much more strongly than an analogous bis(iminodiacetate) probe. In addition, a control tetra(iminodipropionate) probe exhibited no bone targeting ability. The tetra(iminodiacetate) probe targeted the same regions of high bone turnover as the near-infrared bisphosphonate probe OsteoSense750. Longitudinal studies showed that the fluorescence image signal from living mice treated with the tetra(iminodiacetate) probe was much more stable over 19 days than the signal from OsteoSense750. The narrow emission band of the tetra(iminodiacetate) probe makes it very attractive for inclusion in multiplex imaging protocols that employ a mixture of multiple fluorescent probes in preclinical studies of bone growth or in fluorescence guided surgery. The results also suggest that molecules or nanoparticles bearing multivalent iminodiacetate groups have promise as bone targeting agents with tunable properties for various pharmaceutical applications.
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页码:4263 / 4271
页数:9
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共 44 条
[1]
Denosumab and bisphosphonates: Different mechanisms of action and effects
[J].
Baron, Roland
;
Ferrari, Serge
;
Russell, R. Graham G.
.
BONE,
2011, 48 (04)
:677-692

Baron, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Dept Med, Sch Med, Endocrine Unit,Massachusetts Gen Hosp, Boston, MA 02115 USA
Harvard Univ, Dept Oral Med Infect & Immun, Sch Dent Med, Boston, MA 02115 USA Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Nuffield Orthopaed Ctr,Botnar Res Ctr, Oxford OX3 7LD, England

Ferrari, Serge
论文数: 0 引用数: 0
h-index: 0
机构:
Hop Univ, Serv Malad Osseuses, Dept Rehabil & Geriatrie, CH-1211 Geneva 14, Switzerland
Fac Med Geneva, CH-1211 Geneva 14, Switzerland Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Nuffield Orthopaed Ctr,Botnar Res Ctr, Oxford OX3 7LD, England

Russell, R. Graham G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Nuffield Orthopaed Ctr,Botnar Res Ctr, Oxford OX3 7LD, England
Univ Sheffield, Mellanby Ctr Bone Res, Dept Human Metab, Sch Med, Sheffield S10 2RX, S Yorkshire, England Univ Oxford, Inst Musculoskeletal Sci, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Nuffield Orthopaed Ctr,Botnar Res Ctr, Oxford OX3 7LD, England
[2]
Synthesis of conjugatable bisphosphonates for molecular imaging of large animals
[J].
Bhushan, Kumar R.
;
Tanaka, Eiichi
;
Frangioni, John V.
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2007, 46 (42)
:7969-7971

Bhushan, Kumar R.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dep Med, Boston, MA 02215 USA

Tanaka, Eiichi
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dep Med, Boston, MA 02215 USA

Frangioni, John V.
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dep Med, Boston, MA 02215 USA
[3]
Detection of Breast Cancer Microcalcifications Using a Dual-modality SPECT/NIR Fluorescent Probe
[J].
Bhushan, Kumar R.
;
Misra, Preeti
;
Liu, Fangbing
;
Mathur, Sanjeev
;
Lenkinski, Robert E.
;
Frangioni, John V.
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2008, 130 (52)
:17648-+

Bhushan, Kumar R.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

Misra, Preeti
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

Liu, Fangbing
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

Mathur, Sanjeev
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

Lenkinski, Robert E.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA

Frangioni, John V.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Hematol Oncol,Dept Med, Boston, MA 02215 USA
[4]
High Affinity Binding of an Engineered, Modular Peptide to Bone Tissue
[J].
Brounts, Sabrina H.
;
Lee, Jae Sung
;
Weinberg, Sean
;
Levengood, Sheeny K. Lan
;
Smith, Everett L.
;
Murphy, William L.
.
MOLECULAR PHARMACEUTICS,
2013, 10 (05)
:2086-2090

Brounts, Sabrina H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

Lee, Jae Sung
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

Weinberg, Sean
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI 53792 USA Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

Levengood, Sheeny K. Lan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

Smith, Everett L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Populat Hlth Sci, Madison, WI 53706 USA Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

Murphy, William L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA
Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI 53792 USA
AO Fdn, Collaborat Res Ctr, Davos, Switzerland Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA
[5]
STABILITY OF METAL CHELATES .1. IMINODIACETIC AND IMINODIPROPIONIC ACIDS
[J].
CHABEREK, S
;
MARTELL, AE
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1952, 74 (20)
:5052-5056

CHABEREK, S
论文数: 0 引用数: 0
h-index: 0

MARTELL, AE
论文数: 0 引用数: 0
h-index: 0
[6]
Synthesis and In Vivo Fate of Zwitterionic Near-Infrared Fluorophores
[J].
Choi, Hak Soo
;
Nasr, Khaled
;
Alyabyev, Sergey
;
Feith, Dina
;
Lee, Jeong Heon
;
Kim, Soon Hee
;
Ashitate, Yoshitomo
;
Hyun, Hoon
;
Patonay, Gabor
;
Strekowski, Lucjan
;
Henary, Maged
;
Frangioni, John V.
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2011, 50 (28)
:6258-6263

Choi, Hak Soo
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Nasr, Khaled
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Alyabyev, Sergey
论文数: 0 引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Feith, Dina
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Lee, Jeong Heon
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Kim, Soon Hee
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA
Chonbuk Natl Univ, WCU Dept BIN Fus Technol, Jeonju 561756, South Korea Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Ashitate, Yoshitomo
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Hyun, Hoon
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Patonay, Gabor
论文数: 0 引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Strekowski, Lucjan
论文数: 0 引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Henary, Maged
论文数: 0 引用数: 0
h-index: 0
机构:
Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

Frangioni, John V.
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
[7]
Dendritic Poly(ethylene glycol) Bearing Paclitaxel and Alendronate for Targeting Bone Neoplasms
[J].
Clementi, Chiara
;
Miller, Keren
;
Mero, Anna
;
Satchi-Fainaro, Ronit
;
Pasut, Gianfranco
.
MOLECULAR PHARMACEUTICS,
2011, 8 (04)
:1063-1072

Clementi, Chiara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

Miller, Keren
论文数: 0 引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

Mero, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

Satchi-Fainaro, Ronit
论文数: 0 引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy

Pasut, Gianfranco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy
[8]
Water-soluble, deep-red fluorescent squaraine rotaxanes
[J].
Cole, Erin L.
;
Arunkumar, Easwaran
;
Xiao, Shuzhang
;
Smith, Bryan A.
;
Smith, Bradley D.
.
ORGANIC & BIOMOLECULAR CHEMISTRY,
2012, 10 (30)
:5769-5773

Cole, Erin L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Arunkumar, Easwaran
论文数: 0 引用数: 0
h-index: 0
机构:
Mol Targeting Technol Inc, W Chester, PA 19380 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Xiao, Shuzhang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Smith, Bryan A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Smith, Bradley D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[9]
Improved Bone Delivery of Osteoprotegerin by Bisphosphonate Conjugation in a Rat Model of Osteoarthritis
[J].
Doschak, Michael R.
;
Kucharski, Cezary M.
;
Wright, Jennifer E. I.
;
Zernicke, Ronald F.
;
Uludag, Hasan
.
MOLECULAR PHARMACEUTICS,
2009, 6 (02)
:634-640

Doschak, Michael R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Kucharski, Cezary M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2N8, Canada Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Wright, Jennifer E. I.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2N8, Canada Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Zernicke, Ronald F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

Uludag, Hasan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2N8, Canada Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada
[10]
Self-assembly of fluorescent inclusion complexes in competitive media including the interior of living cells
[J].
Gassensmith, Jeremiah J.
;
Arunkumar, Easwaran
;
Barr, Lorna
;
Baumes, Jeffrey M.
;
DiVittorio, Kristy M.
;
Johnson, James R.
;
Noll, Bruce C.
;
Smith, Bradley D.
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
2007, 129 (48)
:15054-15059

Gassensmith, Jeremiah J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Arunkumar, Easwaran
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Barr, Lorna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Baumes, Jeffrey M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

DiVittorio, Kristy M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Johnson, James R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Noll, Bruce C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA

Smith, Bradley D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame, Walther Canc Res Ctr, Dept Chem & Biochem, Notre Dame, IN 46556 USA