Treating Iron Overload

被引：33

作者：

Camaschella, Clara ^{[1
,2
]}

机构：

[1] Univ Vita Salute San Raffaele, Milan, Italy

[2] Ist Sci San Raffaele, I-20132 Milan, Italy

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 368卷 / 24期

关键词：

BETA-THALASSEMIA; MOUSE MODEL; HEMOCHROMATOSIS; MICE;

D O I：

10.1056/NEJMcibr1304338

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：2325 / 2327

页数：3

共 5 条

[1] Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice [J].

Finberg, Karin E. ;

Whittlesey, Rebecca L. ;

Andrews, Nancy C. .

BLOOD, 2011, 117 (17) :4590-4599

[2] Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice [J].

Guo, Shuling ;

Casu, Carla ;

Gardenghi, Sara ;

Booten, Sheri ;

Aghajan, Mariam ;

Peralta, Raechel ;

Watt, Andy ;

Freier, Sue ;

Monia, Brett P. ;

Rivella, Stefano .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (04) :1531-1541

[3] Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia [J].

Nai, Antonella ;

Pagani, Alessia ;

Mandelli, Giacomo ;

Lidonnici, Maria Rosa ;

Silvestri, Laura ;

Ferrari, Giuliana ;

Camaschella, Clara .

BLOOD, 2012, 119 (21) :5021-5029

[4] Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis [J].

Ramos, Emilio ;

Ruchala, Piotr ;

Goodnough, Julia B. ;

Kautz, Leon ;

Preza, Gloria C. ;

Nemeth, Elizabeta ;

Ganz, Tomas .

BLOOD, 2012, 120 (18) :3829-3836

[5] An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia [J].

Schmidt, Paul J. ;

Toudjarska, Iva ;

Sendamarai, Anoop K. ;

Racie, Tim ;

Milstein, Stuart ;

Bettencourt, Brian R. ;

Hettinger, Julia ;

Bumcrot, David ;

Fleming, Mark D. .

BLOOD, 2013, 121 (07) :1200-1208

← 1 →