Total Synthesis of Xestoaminol C from D-Glucose

被引：5
作者：
Vulupala, Hanmanth R. [1 ]
Sajja, Yasodakrishna [1 ]
Bantu, Rajashaker [1 ]
Nagarapu, Lingaiah [1 ]
机构：
[1] CSIR, Indian Inst Chem Technol, Organ Chem Div CPC 2, Hyderabad 500007, Andhra Pradesh, India
来源：
CURRENT ORGANIC CHEMISTRY | 2015年 / 19卷 / 20期
关键词：
Staudinger reaction; Wittig olefination; oxidative cleavage; hydrogenation; D-glucose; POLYETHYLENE-GLYCOL PEG-400; AMINO-ALCOHOLS; ASYMMETRIC-SYNTHESIS; EFFICIENT; SPHINGOSINE; SPHINGOLIPIDS; CHEMISTRY; SAFINGOL; BIOLOGY;
D O I：
10.2174/1385272819666150730214151
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and practical approach for the total synthesis of Xestoaminol C has been accomplished with 16.43% overall yield from commercially available D-glucose. The synthesis involves S(N)2 type centre inversion with azido group, Staudinger reaction, Wittig olefination and Pearlman's catalytic hydrogenation.
引用
收藏
页码：2040 / 2045
页数：6
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