Cellular and cytokine responses in feathers of chickens vaccinated against Marek's disease

被引：18
作者：
Abdul-Careem, M. F.
Hunter, D. B.
Shanmuganathan, S.
Haghighi, H. R.
Read, L.
Heidari, M. [2 ]
Sharif, S. [1 ]
机构：
[1] Univ Guelph, Dept Pathobiol, Ontario Vet Coll, Guelph, ON N1G 2W1, Canada
[2] USDA ARS, Avian Dis & Oncol Lab, E Lansing, MI 48823 USA
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2008年 / 126卷 / 3-4期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Chicken; Marek's disease; Vaccine; CD8+T cell; Interferon;
D O I：
10.1016/j.vetimm.2008.07.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In Marek's disease virus infection, feather follicle epithelium (FFE) constitutes the site of formation of infectious virus particles and virus shedding. The objective of this study was to characterize cellular and cytokine responses as indicators of cell-mediated immune response in FFE and associated feather pulp following immunization against Marek's disease. Analysis of feather tips collected between 4 and 28 days post-immunization (d.p.i.) front chickens vaccinated post-hatch with either CVI988/Rispens or herpesvirus of turkeys revealed that replication of these vaccine Viruses started at 7 d.p.i., peaked by 2 1 d.p.i., and Subsequently, showed a declining trend. This pattern of viral replication, which led to viral genome accumulation in feather tips, was associated with infiltration of T cell subsets particularly CD8+ T cells into the feather pulp area and the expression of cytokine genes such as interferon-gamma, which is an indication of elicitation of cell-mediated immune responses at the site of virus shedding. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：362 / 366
页数：5
相关论文
共 29 条
[1]   Host responses are induced in feathers of chickens infected with Marek's disease virus [J].
Abdul-Careem, M. F. ;
Hunter, B. D. ;
Sarson, A. J. ;
Parvizi, P. ;
Haghighi, H. R. ;
Read, L. ;
Heidari, M. ;
Sharif, S. .
VIROLOGY, 2008, 370 (02) :323-332
[2]   Marek's disease virus-induced transient paralysis is associated with cytokine gene expression in the nervous system [J].
Abdul-Careem, M. F. ;
Hunter, B. D. ;
Sarson, A. J. ;
Mayameei, A. ;
Zhou, H. ;
Sharif, S. .
VIRAL IMMUNOLOGY, 2006, 19 (02) :167-176
[3]   Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys [J].
Abdul-Careem, Mohamed Faizal ;
Hunter, D. Bruce ;
Lambourne, Melissa D. ;
Read, Leah R. ;
Parvizi, Payvand ;
Sharif, Shayan .
VACCINE, 2008, 26 (19) :2369-2377
[4]   Cytokine gene expression patterns associated with immunization against Marek's disease in chickens [J].
Abdul-Careem, Mohamed Faizal ;
Hunter, Bruce D. ;
Parvizi, Payvand ;
Haghighi, Hamid R. ;
Thanthrige-Don, Niroshan ;
Sharif, Shayan .
VACCINE, 2007, 25 (03) :424-432
[5]   Development of a real-time PCR assay using SYBR Green chemistry for monitoring Marek's disease virus genome load in feather tips [J].
Abdul-Careem, Mohamed Faizal ;
Hunter, Bruce D. ;
Nagy, Eva ;
Read, Leah R. ;
Sanei, Babak ;
Spencer, J. Lloyd ;
Sharif, Shayan .
JOURNAL OF VIROLOGICAL METHODS, 2006, 133 (01) :34-40
[6]   Replication kinetics of Marek's disease vaccine virus in feathers and lymphoid tissues using PCR and virus isolation [J].
Baigent, SJ ;
Smith, LP ;
Currie, RJW ;
Nair, VK .
JOURNAL OF GENERAL VIROLOGY, 2005, 86 :2989-2998
[7]   Vaccinal control of Marek's disease: Current challenges, and future strategies to maximize protection [J].
Baigent, Susan J. ;
Smith, Lorraine P. ;
Nair, Venugopal K. ;
Currie, Richard J. W. .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2006, 112 (1-2) :78-86
[8]  
BEASLEY JN, 1970, AM J VET RES, V31, P339
[9]   Gene expression profiling of chicken lymphoid cells after treatment with Lactobacillus acidophilus cellular components [J].
Brisbin, Jennifer T. ;
Zhou, Huaijun ;
Gong, Joshua ;
Sabour, Parviz ;
Akbari, Mohammad Reza ;
Haghighi, Hamid Reza ;
Yu, Hai ;
Clarke, Anthony ;
Sarson, Aimie Jey ;
Sharif, Shayan .
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2008, 32 (05) :563-574
[10]   FEATHER FOLLICLE EPITHELIUM - A SOURCE OF ENVELOPED AND INFECTIOUS CELL-FREE HERPESVIRUS FROM MAREKS DISEASE [J].
CALNEK, BW ;
ADLDINGER, HK ;
KAHN, DE .
AVIAN DISEASES, 1970, 14 (02) :219-+
123