Venous Thromboembolism in COVID-19

被引：62

作者：

Schulman, Sam ^{[1
,2
]}

Hu, Yu ^{[3
]}

Konstantinides, Stavros ^{[4
,5
]}

机构：

[1] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Dept Med, Hamilton, ON, Canada

[2] IM Sechenov First Moscow State Med Univ, Dept Obstet & Gynecol, Moscow, Russia

[3] Huazhong Univ Sci & Technol, Inst Hematol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China

[4] Univ Med Ctr Mainz, Ctr Thrombosis & Hemostasis, Mainz, Germany

[5] Democritus Univ Thrace, Dept Cardiol, Thrace, Greece

来源：

THROMBOSIS AND HAEMOSTASIS | 2020年 / 120卷 / 12期

关键词：

COVID-19; D-dimer; risk assessment models; venous thromboembolism; prophylaxis; treatment; ACUTE PULMONARY-EMBOLISM; DEEP-VEIN THROMBOSIS; CLINICAL CHARACTERISTICS; MEDICAL PATIENTS; RISK; PNEUMONIA; INFECTION; THERAPY; IMPACT;

D O I：

10.1055/s-0040-1718532

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The coronavirus disease 2019 (COVID-19) is our latest pandemic, preceded by the H1N1 swine flu in 2009, which lasted approximately 19 months. One of the special characteristics of COVID-19 is the propensity to cause venous thromboembolism (VTE). Thromboinflammation seems to play a prominent role in the pathogenesis. We will here review some mechanisms in the pathogenesis and discuss some hematological biomarkers, and also whether they serve as useful risk factors for VTE. The role of general risk assessment models for medically ill patients specifically in COVID-19 is appraised. The type of prophylaxis and particularly whether standard or augmented doses of chemoprophylaxis should be used is reviewed based on available evidence. We are also comparing recommendations from 10 different guidance or position/consensus statements. Treatment recommendations for patients with COVID-19 and pulmonary embolism are discussed with current general treatment guidelines as reference. Specifics for patients with COVID-19 are pointed out and the potential role of thrombolytic treatment is explored.

引用

页码：1642 / 1653

页数：12

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