Mitochondrial Haplogroups Are Associated With Clinical Pattern of AIDS Progression in HIV-Infected Patients

被引：21

作者：

Guzman-Fulgencio, Maria ^{[1
]}

Luis Jimenez, Jose ^{[2
]}

Garcia-Alvarez, Monica ^{[1
]}

Maria Bellon, Jose ^{[3
]}

Fernandez-Rodriguez, Amanda ^{[1
]}

Campos, Yolanda ^{[4
]}

Rodriguez, Carmen ^{[5
]}

Gonzalez-Garcia, Juan ^{[6
]}

Riera, Melchor ^{[7
]}

Viciana, Pompeyo ^{[8
]}

Angeles Munoz-Fernandez, Ma ^{[9
,10
,11
]}

Resino, Salvador ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Coinfecc HIV Hepatitis, Madrid 28220, Spain

[2] Hosp Gen Univ Gregorio Maranon, Plataforma Lab, Madrid, Spain

[3] Hosp Gen Univ Gregorio Maranon, Fdn Invest Biomed, Madrid, Spain

[4] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Patol Mitocondrial, Madrid 28220, Spain

[5] Ctr Sanitario Sandoval, Madrid, Spain

[6] Hosp Univ La Paz, Serv Med Interna, Madrid, Spain

[7] Hosp Univ Son Espases, Serv Med Interna Infecciosas, Palma De Mallorca, Spain

[8] Hosp Virgen Rocio, Serv Enfermedades Infecciosas, Seville, Spain

[9] Hosp Gen Univ Gregorio Maranon, Lab Inmunobiol Mol, Madrid, Spain

[10] CIBER BBN, Madrid, Spain

[11] HGUGM CSIC, Unidad Retrovirl Humana, Madrid, Spain

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2013年 / 63卷 / 02期

关键词：

AIDS; mitochondria; haplogroups; mtDNA; polymorphisms; LTNPs; ACTIVE ANTIRETROVIRAL THERAPY; DNA HAPLOGROUPS; COINFECTED PATIENTS; APOPTOSIS; DEFENSE; BIOBANK; VIRUS;

D O I：

10.1097/QAI.0b013e3182893f74

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a cross-sectional study in 469 HIV-infected patients, whose mitochondrial haplogroups were genotyped to study their association with the clinical pattern of AIDS progression. The chance of not having an AIDS progression was 1.45 [95% of confidence interval (CI) = 1.02 to 2.05, P = 0.035) times greater in patients with cluster HV and 1.51 (95% CI = 1.06 to 2.18, P = 0.021) times greater in patients with haplogroup H. However, we only found significant values for haplogroup H (odds ratio = 1.52, 95% CI = 1.01 to 2.32, P = 0.049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression.

引用

页码：178 / 183

页数：6

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