Evolution of simple sequence repeat-mediated phase variation in bacterial genomes

被引：26

作者：

Bayliss, Christopher D. ^{[1
]}

Palmer, Michael E. ^{[2
]}

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

[2] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

来源：

EFFECTS OF GENOME STRUCTURE AND SEQUENCE ON VARIATION AND EVOLUTION | 2012年 / 1267卷

关键词：

phase variation; simple sequence repeat; bacteria; pathogen; HAEMOPHILUS-INFLUENZAE; NEISSERIA-MENINGITIDIS; ANTIGENIC VARIATION; MISMATCH REPAIR; GENES; REPLICATION; MUTATIONS; FITNESS; ESCAPE; SYSTEM;

D O I：

10.1111/j.1749-6632.2012.06584.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutability as mechanism for rapid adaptation to environmental challenge is an alluringly simple concept whose apotheosis is realized in simple sequence repeats (SSR). Bacterial genomes of several species contain SSRs with a proven role in adaptation to environmental fluctuations. SSRs are hypermutable and generate reversible mutations in localized regions of bacterial genomes, leading to phase variable ON/OFF switches in gene expression. The application of genetic, bioinformatic, and mathematical/computational modeling approaches are revolutionizing our current understanding of how genomic molecular forces and environmental factors influence SSR-mediated adaptation and led to evolution of this mechanism of localized hypermutation in bacterial genomes.

引用

页码：39 / 44

页数：6

共 30 条

[1] Pathogen escape from host immunity by a genome program for antigenic variation [J].

Barbour, Alan G. ;

Dai, Qiyuan ;

Restrepo, Blanca I. ;

Stoenner, Herbert G. ;

Frank, Steven A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (48) :18290-18295

[2] Genome hyperevolution and the success of a parasite [J].

Barry, J. David ;

Hall, James P. J. ;

Plenderleith, Lindsey .

EFFECTS OF GENOME STRUCTURE AND SEQUENCE ON VARIATION AND EVOLUTION, 2012, 1267 :11-17

[3]

Bayliss C.D, 2012, NUC ACIDS RES, V33, P504

[4] Mutations in poll but not mutSLH destabilize Haemophilus influenzae tetranucleotide repeats [J].

Bayliss, CD ;

van de Ven, T ;

Moxon, ER .

EMBO JOURNAL, 2002, 21 (06) :1465-1476

[5] The simple sequence contingency loci of Haemophilus influenzae and Neisseria meningitidis [J].

Bayliss, CD ;

Field, D ;

Moxon, ER .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (06) :657-662

[6] Neisseria meningitidis Escape from the Bactericidal Activity of a Monoclonal Antibody Is Mediated by Phase Variation of lgtG and Enhanced by a Mutator Phenotype [J].

Bayliss, Christopher D. ;

Hoe, J. Claire ;

Makepeace, Katherine ;

Martin, Patricia ;

Hood, Derek W. ;

Moxon, E. Richard .

INFECTION AND IMMUNITY, 2008, 76 (11) :5038-5048

[7] High allelic diversity in the methyltransferase gene of a phase variable type III restriction-modification system has implications for the fitness of Haemophilus influenzae [J].

Bayliss, Christopher D. ;

Callaghan, Martin J. ;

Moxon, E. Richard .

NUCLEIC ACIDS RESEARCH, 2006, 34 (14) :4046-4059

[8] Determinants of phase variation rate and the fitness implications of differing rates for bacterial pathogens and commensals [J].

Bayliss, Christopher D. .

FEMS MICROBIOLOGY REVIEWS, 2009, 33 (03) :504-520

[9] Campylobacter bacteriophages and bacteriophage therapy [J].

Connerton, P. L. ;

Timms, A. R. ;

Connerton, I. F. .

JOURNAL OF APPLIED MICROBIOLOGY, 2011, 111 (02) :255-265

[10] The length of a tetranucleotide repeat tract in Haemophilus influenzae determines the phase variation rate of a gene with homology to type III DNA methyltransferases [J].

De Bolle, X ;

Bayliss, CD ;

Field, D ;

van de Ven, T ;

Saunders, NJ ;

Hood, DW ;

Moxon, ER .

MOLECULAR MICROBIOLOGY, 2000, 35 (01) :211-222

← 1 2 3 →