Cytotoxic Limonoids from Melia azedarach

被引：30

作者：

Yuan, Chun-Mao ^{[2
]}

Zhang, Yu ^{[2
]}

Tang, Gui-Hua ^{[2
]}

Li, Yan ^{[2
]}

He, Hong-Ping ^{[2
]}

Li, Shi-Fei ^{[2
]}

Hou, Li ^{[2
]}

Li, Xing-Yao ^{[2
]}

Di, Ying-Tong ^{[2
]}

Li, Shun-Lin ^{[2
]}

Hua, Hui-Ming ^{[1
]}

Hao, Xiao-Jiang ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Sch Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[2] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

来源：

PLANTA MEDICA | 2013年 / 79卷 / 02期

关键词：

Melia azedarach Linn; Meliaceae; limonoids; chemical constituents; cytotoxicities; AZADIRACHTA-INDICA; TOOSENDAN; TRITERPENOIDS; LEAVES; FRUITS; TERPENOIDS; CHEMISTRY; SKELETON;

D O I：

10.1055/s-0032-1328069

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as well as three acetylated derivatives of 9 were evaluated for their cytotoxicities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by an MTT assay. Seven limonoids (1, 6, 7, 8, 9, 9b, and 9c) showed significant inhibitory activities against tested cell lines with IC50 values ranging from 0.003 to 0.555 mu M, and their preliminary structure-activity relationships are also discussed.

引用

页码：163 / 168

页数：6

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