Origin of humoral hemolytic factors in patients with chronic renal failure

The study of erythrodieresis intensity as well as that of its humoral component with identification of hemolytic factors of patients with chronic renal failure (termal phase) on programmed hemodialysis (HD) showed development of anemia. This is due to intensive red cell destruction induced by enhanced hemolytic activity of the blood serum dependent on both the presence of medium-size peptides the number of which lessens in the course of hemodialysis and growing to the end of the session number of humoral hemolytic factors having molecular mass 80-100 kD. These findings should be considered when estimating efficacy of red cell mass infusions for patients with chronic renal failure basing on parameters of serum hemolytic activity and resistance of donor red cells to hemolyzing effects of the recipient's serum.