Chemical constituents of Aeschynanthus bracteatus and their weak anti-inflammatory activities

被引：27

作者：

Li, Su-Mei ^{[1
,2
,3
]}

Yang, Xian-Wen ^{[2
]}

Shen, Yun-Heng ^{[2
]}

Feng, Lin ^{[4
]}

Wang, Yue-Hu ^{[1
]}

Zeng, Hua-Wu ^{[2
]}

Liu, Xiao-Hua ^{[2
]}

Tian, Jun-Mian ^{[2
]}

Shi, Ya-Na ^{[1
]}

Long, Chun-Lin ^{[1
,5
]}

Zhang, Wei-Dong ^{[2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Second Mil Med Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 200433, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[4] Jiangxi Univ Tradit Chinese Med, Dept Pharm, Nanchang 330004, Peoples R China

[5] Cent Univ Nationalities, Coll Life & Environm Sci, Beijing 100081, Peoples R China

来源：

PHYTOCHEMISTRY | 2008年 / 69卷 / 11期

关键词：

Aeschynanthus bracteatus; Gesneriaceae; phenylethanoids; aeschynanthosides A-D; RAW; 264.7; macrophages; anti-inflammatory; NO;

D O I：

10.1016/j.phytochem.2008.05.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical examination of the EtOAc extract from the aerial parts of Aeschynanthus bracteatus led to isolation of four phenylethanol glycosides, aeschynanthosides A-D (1-4), and 55 known constituents, including 8 phenylethanoids, 23 phenols, 5 lignans, 7 flavonoids, 9 terpenoids, and 4 others. Their structures were elucidated mainly by detailed spectroscopic studies and comparison with published data. All 59 compounds were isolated for the first time from an Aeschynanthus species. The isolates were also tested for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Aeschynanthoside D (4) and naringenin (41), within the concentration arrange tested (50-100 mu g/mL), showed very weak dose-dependent effects with the inhibition rate of 24.2%, 35.4%, 66.0%, and 9.5%, 40.1%, 65.0%, respectively, relative to positive controls. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2200 / 2204

页数：5

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