Evaluation of DNA damage in jewellery workers occupationally exposed to nitric oxide

被引：6

作者：

Jayakumar, Rajarajeswaran ^{[1
]}

Sasikala, Keshavrao ^{[1
]}

机构：

[1] Bharathiar Univ, Dept Zool, Human Genet Unit, Coimbatore 641046, Tamil Nadu, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2008年 / 26卷 / 02期

关键词：

reactive nitrogen species; DNA damage; buccal cell comet assay;

D O I：

10.1016/j.etap.2008.03.016

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nitric oxide is a metastable radical, reacts with oxygen to produce toxic nitrogen oxides (N(2)O(3), ONOO(-)) which damage DNA. Occupational exposure to nitric oxide leads to increased frequency of chromosomal aberrations in humans. In the present Study the DNA damage among the jewellery workers occupationally exposed to nitric oxide was analyzed using buccal cell comet assay. The result of this study shows increased levels of DNA damage among jewellery workers. The habit of cigarette smoking among the jewellery workers has a synergistic effect on inducing DNA damage. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：259 / 261

页数：3

共 28 条

[1] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].