Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication

被引：7

作者：

Zhang, Huixia ^{[1
,2
]}

Gao, Shanshan ^{[1
,2
]}

Pei, Rongjuan ^{[1
]}

Chen, Xinwen ^{[1
]}

Li, Chaoyang ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Virol, Ctr Mol Virol, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China

[2] Univ Chinese Acad Sci, Chinese Acad Sci, Beijing 100000, Peoples R China

来源：

VIROLOGICA SINICA | 2017年 / 32卷 / 06期

基金：

美国国家科学基金会;

关键词：

hepatitis C virus (HCV); NS3; NS5B; prion protein (PrP); PRO-PRION; SOFOSBUVIR; INFECTION; REACTIVATION; RIBAVIRIN; NEURONS; BINDING; PANEL; GENE; NS3;

D O I：

10.1007/s12250-017-4039-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis C virus (HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein (PrP) was induced in an HCV replication cell model. We then showed that increased PrP expression facilitated HCV genomic replication. Finally, we demonstrated that the KKRPK motif on the N-terminus of PrP bound nucleic acids and facilitated HCV genomic replication. Our results provided important insights into how viruses may harness cellular protein to achieve propagation.

引用

页码：503 / 510

页数：8

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