Long noncoding RNA MIR4435-2HG promotes hepatocellular carcinoma proliferation and metastasis through the miR-22-3p/YWHAZ axis

被引：5
作者：
Shen, Xuanlin [1 ]
Ding, Yuting [1 ]
Lu, Feng [2 ]
Yuan, Haitao [3 ]
Luan, Wenkang [2 ]
机构：
[1] Yangzhou Univ, Clin Med Coll 5, Dept Rehabil, Changshu Peoples Hosp 2, 68 Haiyu South Rd, Changshu 215500, Jiangsu, Peoples R China
[2] Jiangsu Univ, Dept Plast Surg, Affiliated Peoples Hosp, 8 Dianli Rd, Zhenjiang 212000, Jiangsu, Peoples R China
[3] Jiangsu Univ, Dept Gen Surg, Affiliated Peoples Hosp, Zhenjiang, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2020年 / 12卷 / 10期
基金：
中国国家自然科学基金;
关键词：
HCC; proliferation and metastasis; MIR4435-2HG; miR-22-3p; YWHAZ; GLUCOSE-METABOLISM; CANCER; EPIDEMIOLOGY; EXPRESSION; GROWTH; CERNA; YWHAZ; HCC;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long noncoding RNAs (lncRNAs) play the critical biological role in many malignant tumours. MIR4435-2HG has been proven to be a novel oncogenic lncRNA. However, the exact role and mechanism of MIR4435-2HG in hepatocellular carcinoma (HCC) remain unclear. Here, we found that MIR4435-2HG is overexpressed in HCC tissue compared to normal controls and that high level of MIR4435-2HG indicates a poorer prognosis in HCC patients. MIR4435-2HG enhances the growth and metastasis ability of HCC cells. MIR4435-2HG promotes the expression of YWHAZ by sponging miR-22-3p to liberate YWHAZ mRNA transcripts. MIR4435-2HG facilitates the proliferation and metastasis of HCC by modulating the miR-22-3p/YWHAZ axis. These results demonstrated the role and mechanism of MIR4435-2HG in malignant progression of HCC. MIR4435-2HG may be used as the prognostic marker and treatment target for the patient with HCC.
引用
收藏
页码：6381 / 6394
页数：14
相关论文
共 36 条
  • [1] Changing Hepatocellular Carcinoma Incidence and Liver Cancer Mortality Rates in the United States
    Altekruse, Sean F.
    Henley, S. Jane
    Cucinelli, James E.
    McGlynn, Katherine A.
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2014, 109 (04) : 542 - 553
  • [2] A Novel Function of YWHAZ/β-Catenin Axis in Promoting Epithelial-Mesenchymal Transition and Lung Cancer Metastasis
    Chen, Ching-Hsien
    Chuang, Show-Mei
    Yang, Meng-Fang
    Liao, Jiunn-Wang
    Yu, Sung-Liang
    Chen, Jeremy J. W.
    [J]. MOLECULAR CANCER RESEARCH, 2012, 10 (10) : 1319 - 1331
  • [3] Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma
    Dimri, Manali
    Satyanarayana, Ande
    [J]. CANCERS, 2020, 12 (02)
  • [4] Long Non-coding RNA MIR4435-2HG Promotes Colorectal Cancer Proliferation and Metastasis Through miR-206/YAP1 Axis
    Dong, Xinhua
    Yang, Zhen
    Yang, Hongwei
    Li, Dongyan
    Qiu, Xinguang
    [J]. FRONTIERS IN ONCOLOGY, 2020, 10
  • [5] Dufour Jean-Francois, 2010, J Hepatol, V52, P296, DOI 10.1016/j.jhep.2009.11.010
  • [6] Non-coding RNAs in human disease
    Esteller, Manel
    [J]. NATURE REVIEWS GENETICS, 2011, 12 (12) : 861 - 874
  • [7] The role of YWHAZ in cancer: A maze of opportunities and challenges
    Gan, Yun
    Yee, Feng
    He, Xing-Xing
    [J]. JOURNAL OF CANCER, 2020, 11 (08): : 2252 - 2264
  • [8] The hallmarks of cancer A long non-coding RNA point of view
    Gutschner, Tony
    Diederichs, Sven
    [J]. RNA BIOLOGY, 2012, 9 (06) : 703 - 719
  • [9] The lncRNA MIR4435-2HG is upregulated in hepatocellular carcinoma and promotes cancer cell proliferation by upregulating miRNA-487a
    Kong, Qinglei
    Liang, Caiqian
    Jin, Yi
    Pan, Yuhang
    Tong, Dayue
    Kong, Qingcong
    Zhou, Jing
    [J]. CELLULAR & MOLECULAR BIOLOGY LETTERS, 2019, 24 (1)
  • [10] Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling
    Lingadahalli, Shreyas
    Jadhao, Sudhir
    Sung, Ying Ying
    Chen, Mi
    Hu, Lingling
    Chen, Xin
    Cheung, Edwin
    [J]. MOLECULAR CANCER RESEARCH, 2018, 16 (12) : 1865 - 1878
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