Relationship between NRAMP1 gene polymorphism and efficacy of BCG vaccine in a helminth-infected population

被引：5

作者：

Badawy, A. A. ^{[1
]}

Yahya, R. S. ^{[2
]}

Awad, S. I. ^{[3
]}

Al-Sawah, G. A. ^{[2
]}

Kizilbash, N. A. ^{[4
]}

机构：

[1] Mansoura Univ, Dept Med Biochem, Fac Med, Mansoura, Egypt

[2] Mansoura Univ, Childrens Hosp, Fac Med, Mansoura, Egypt

[3] Mansoura Univ, Dept Parasitol, Fac Med, Mansoura, Egypt

[4] Northern Border Univ, Dept Biochem, Fac Med, Ar Ar, Saudi Arabia

来源：

GENETICS AND MOLECULAR RESEARCH | 2013年 / 12卷 / 03期

关键词：

NRAMP1 gene polymorphism; Tuberculosis; Helminths; BCG vaccine; SCHISTOSOMA-MANSONI; NATURAL-RESISTANCE; TUBERCULIN REACTIVITY; INTESTINAL HELMINTH; MACROPHAGE PROTEIN; SUSCEPTIBILITY; CHILDREN; IDENTIFICATION; TRANSPORT; PARASITES;

D O I：

10.4238/2013.January.30.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infection of mothers with schistosomiasis and filariasis has been shown to influence infant responses to neonatal Bacille Calmette-Guerin (BCG) immunization. The genetic makeup of infants is also considered an important determinant for the activity of BCG vaccine. The effect of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphism on the efficacy of BCG vaccine was examined in neonates with helminth-infected mothers (63 infants) and the results were compared with neonates of uninfected mothers (187 infants). After BCG vaccination, assessment of scar presence, tuberculin test, stool analysis, and IgE level was performed. Polymorphism of the NRAMP1 gene was investigated by PCR amplification followed by RFLP analysis. We found that patients with heterozygosity of intron 4 (GC) and/or maternal infection with helminth parasites showed reduced efficacy of BCG vaccine against tuberculosis.

引用

页码：3048 / 3056

页数：9

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