Postprandial lipoprotein metabolism and atherosclerosis

被引：286

作者：

Karpe, F ^{[1
]}

机构：

[1] Radcliffe Infirm, Oxford Lipid Metab Grp, Oxford OX2 6HE, England

[2] Karolinska Hosp, Dept Med, King Gustaf V Res Inst, S-10401 Stockholm, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 1999年 / 246卷 / 04期

关键词：

apolipoprotein B-48; apolipoprotein B-100; atherosclerosis; triglyceride-rich lipoproteins; TRL remnants; VLDL;

D O I：

10.1046/j.1365-2796.1999.00548.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Postprandial lipids and lipoproteins have been associated with the presence of cardiovascular disease in a large number of case-control studies. Because the metabolic perturbations around the postprandial situation is a key driving force for cholesterol flux between lipoproteins and tissues, together with the augmented generation of potentially atherogenic cholesterol-rich remnant lipoproteins, several hypotheses have been formulated to link excessive lipoproteinaemic response to fat intake with cardiovascular disease. Recent information on the regulation of lipoprotein remnant formation and its relation Ito atherosclerosis will enable us to test a pertinent clinical question: is there a direct relationship between repeated elevations of postprandial lipoproteins and development of atherosclerosis?

引用

页码：341 / 355

页数：15

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