Differentiation therapy for IDH1/2 mutant malignancies

被引：8

作者：

Garrett-Bakelman, Francine E. ^{[1
]}

Melnick, Ari M. ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Div Hematol Oncol, Dept Med, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA

来源：

CELL RESEARCH | 2013年 / 23卷 / 08期

关键词：

MUTATIONS; LEUKEMIA; GLIOMA; CELLS; IDH2;

D O I：

10.1038/cr.2013.73

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently discovered recurrent somatic mutations in the key metabolic enzymes IDH1 and IDH2 produce the aberrant oncometabolite2-HG and contribute to malignant transformation of hematopoietic and glial cells. Two recent reports in Science describe the first IDH1 and IDH2 mutant-specific small-molecule inhibitors, which induce cell differentiation of myeloid leukemias and malignant gliomas.

引用

页码：975 / 977

页数：3

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