Interactions of miR-34b/c and TP53 Polymorphisms on the Risk of Intracranial Aneurysm

被引：27

作者：

Li, Lijuan ^{[1
,2
]}

Sima, Xiutian ^{[3
]}

Bai, Peng ^{[2
]}

Zhang, Lushun ^{[2
]}

Sun, Hong ^{[1
]}

Liang, Weibo ^{[2
]}

Liu, Jianxing ^{[4
]}

Zhang, Lin ^{[1
,2
,5
]}

Gao, Linbo ^{[1
,5
]}

机构：

[1] Sichuan Univ, W China Univ Hosp 2, W China Inst Women & Childrens Hlth, Lab Mol & Translat Med, Chengdu 610041, Peoples R China

[2] Sichuan Univ, W China Sch Preclin & Forens Med, Dept Forens Biol, Chengdu 610041, Peoples R China

[3] Sichuan Univ, W China Hosp, Dept Neurosurg, Chengdu 610041, Peoples R China

[4] Kunming Med Univ, Dept Forens Med, Kunming 650031, Peoples R China

[5] Minist Educ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Chengdu 610041, Sichuan, Peoples R China

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

TUMOR-SUPPRESSOR P53; SUBARACHNOID HEMORRHAGE; INFLAMMATORY RESPONSE; EXPRESSION PROFILES; CEREBRAL ANEURYSMS; GENE-EXPRESSION; NITRIC-OXIDE; ACTIVATION; LINKAGE; CANCER;

D O I：

10.1155/2012/567586

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several lines of evidence indicate that inflammatory processes play a key role in the happening and development of intracranial aneurysm (IA). Recently, polymorphisms in the TP53 gene were shown to be associated with inflammation and inflammatory disease. The aim of this study was to investigate the interactions of miR-34b/c and TP53 Arg72-Pro polymorphisms on the risk of IA in a Chinese population. A total of 590 individuals (including 164 patients with IA and 426 controls) were involved in this study. The polymorphisms (i.e., miR-34b/c rs4938723 and TP53 Arg72-Pro) were genotyped by polymerase chain reaction-restriction fragment length polymorphism assay and DNA sequencing. We found that the CC genotype of miR-34b/c rs4938723 was significantly associated with a decreased risk of IA compared with the TT genotype. Moreover, a significant gene interaction of the carriers with the combined genotypes of miR-34b/c rs4938723CC and TP53 Arg72Pro CG/CC/GG had a decreased risk of IA, compared with those carrying miR-34b/c rs4938723CT/TT+TP53 Arg72Pro GG/CG/CC combined genotypes. These findings suggest that the miR-34b/c rs4938723CC and TP53 Arg72-Pro polymorphisms may be involved in the susceptibility to IA.

引用

页数：7

共 73 条

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