Association between CASR Polymorphisms, Calcium Intake, and Colorectal Cancer Risk

被引：12
作者：
Kim, Kyee-Zu [1 ]
Shin, Aesun [1 ]
Kim, Jeongseon [1 ]
Park, Ji Won [2 ]
Park, Sung Chan [2 ]
Choi, Hyo Seong [2 ]
Chang, Hee Jin [2 ]
Kim, Dae Yong [2 ]
Oh, Jae Hwan [2 ]
机构：
[1] Natl Canc Ctr, Res Inst, Mol Epidemiol Branch, Goyang Si, South Korea
[2] Natl Canc Ctr Hosp, Ctr Colorectal Canc, Natl Canc Ctr, Goyang Si, South Korea
来源：
PLOS ONE | 2013年 / 8卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
VITAMIN-D-RECEPTOR; METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR; EPITHELIAL-CELL PROLIFERATION; SENSING RECEPTOR; DIETARY CALCIUM; COLON-CANCER; EXTRACELLULAR CALCIUM; GENE POLYMORPHISMS; EXPRESSION; FOLATE;
D O I：
10.1371/journal.pone.0059628
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Aim: The current study aimed to assess the effect of dietary calcium intake and possible interactions with calcium-sensing receptor (CASR) gene polymorphisms on colorectal cancer risk. Methods: A total of 420 colorectal cancer cases and 815 controls were included in the analysis. Calcium intake was investigated using a 103 item semi-quantitative food frequency questionnaire, and four single nucleotide polymorphisms (SNPs) within the CASR, rs10934578, rs12485716, rs2270916, and rs4678174, were evaluated. Results: No SNPs were associated with colorectal cancer risk after adjusting for covariates. Overall, no significant effect modification by CASR polymorphisms on the association between calcium intake and colorectal cancer risk were detected. However, all 4 of the polymorphisms within the CASR showed significantly higher odds ratios for association with colorectal cancer risk in the low-calcium-intake group compared to the high-calcium-intake group. In the case of rs2270916, individuals with the CC genotype and low calcium intake showed an increased colorectal cancer risk compared to their counterparts with the TT genotype and high calcium intake (OR = 2.11, 95% CI = 1.27-3.51). Conclusions: Subjects with lower calcium intake exhibited a higher colorectal cancer risk compared with subjects with the same genotype who had higher calcium intake. Our results suggest that individuals who have low dietary calcium intake should be aware of their increased colorectal cancer risk and prevention strategies.
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页数：6
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