Erectile dysfunction: Pathophysiologic mechanisms pointing to underlying cardiovascular disease

被引：41

作者：

Ganz, P ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 96卷 / 12B期

关键词：

D O I：

10.1016/j.amjcard.2005.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence exists that erectile dysfunction (ED) is analogous to endothelial dysfunction, a known precursor to atherosclerosis in terms of molecular mechanisms and underlying risk factors. These findings are discussed, along with the biologic underpinnings for the clinical observation that ED is an "early warning system" for atherosclerosis. Molecular mechanisms of ED as potential targets of novel therapies are considered, as well as the role of phosphodiesterase 5 inhibitors-currently the most effective treatment of ED-as promising therapies of cardiovascular diseases characterized by endothelial dysfunction. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：8M / 12M

页数：5

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