Adaptive thermogenesis in adipocytes: Is beige the new brown?

被引：656

作者：

Wu, Jun ^{[1
,2
]}

Cohen, Paul ^{[1
,2
,3
]}

Spiegelman, Bruce M. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiovasc,Dept Med, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2013年 / 27卷 / 03期

关键词：

brown fat; beige fat; obesity; adaptive thermogenesis; UCP1; WHITE ADIPOSE-TISSUE; MITOCHONDRIAL UNCOUPLING-PROTEIN; DIET-INDUCED THERMOGENESIS; PPAR-GAMMA ACTIVATION; GROWTH-FACTOR-BETA; ENERGY-EXPENDITURE; SKELETAL-MUSCLE; MICE LACKING; GENE-EXPRESSION; INSULIN-RESISTANCE;

D O I：

10.1101/gad.211649.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

One of the most promising areas in the therapeutics for metabolic diseases centers around activation of the pathways of energy expenditure. Brown adipose tissue is a particularly appealing target for increasing energy expenditure, given its amazing capacity to transform chemical energy into heat. In addition to classical brown adipose tissue, the last few years have seen great advances in our understanding of inducible thermogenic adipose tissue, also referred to as beige fat. A deeper understanding of the molecular processes involved in the development and function of these cell types may lead to new therapeutics for obesity, diabetes, and other metabolic diseases.

引用

页码：234 / 250

页数：17

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