Interaction Between Estrogen Receptor Alpha and Insulin/IGF Signaling in Breast Cancer

被引：71

作者：

Lanzino, Marilena ^{[1
]}

Morelli, Catia ^{[1
]}

Garofalo, Cecilia ^{[1
]}

Panno, Maria Luisa ^{[2
]}

Mauro, Loredana ^{[2
]}

Ando, Sebastiano ^{[2
]}

Sisci, Diego ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Farmacobiol, I-87036 Arcavacata Di Rende, CS, Italy

[2] Univ Calabria, Dept Cellular Biol, I-87036 Arcavacata Di Rende, CS, Italy

来源：

CURRENT CANCER DRUG TARGETS | 2008年 / 8卷 / 07期

关键词：

Estrogen receptor; IGF-I; IGF-IR; Shc; IRS-1; PI3K; Akt; MNAR; ErbB; EGFR; HER2/neu;

D O I：

10.2174/156800908786241104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogens and insulin/Insulin like growth factor I (IGF-I) have potent positive effects on the proliferation of mammary epithelial cells and estrogen-dependent breast cancer cells. A cooperative crosstalk between estrogens and insulin/IGF-I signaling pathways exists and it plays a critical role in breast carcinogenesis, tumor cell proliferation, differentiation and survival through the modulation of multiple biological events. The biological effects of estrogens are mainly mediated by the activation of estrogen receptor (ER whose activity is deeply influenced by the insulin/IGF-I signaling pathway. On the other hand, estrogens enhance insulin signaling by increasing the expression and/or the functional activity of some proteins involved in the insulin/IGF-I pathway. This review will focus on the critical node of the IGF-I network involved in the crosstalk with ER and implicated in breast cancer development and progression.

引用

页码：597 / 610

页数：14

共 202 条

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