Sequence-specific inhibition of a design metallopeptide catalyst

被引：23

作者：

Popp, Brian V. ^{[1
]}

Chen, Zhen ^{[1
]}

Ball, Zachary T. ^{[1
]}

机构：

[1] Rice Univ, Dept Chem MS60, Houston, TX 77005 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 60期

基金：

美国国家科学基金会;

关键词：

HELICAL COILED-COILS; PROTEIN; LOGIC;

D O I：

10.1039/c2cc33808d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rhodium metallopeptides catalyze proximity-driven modification of peptide and protein substrates with enzyme-like selectivity. In this communication, we demonstrate that designed metallopeptide catalysts can be inhibited in a sequence-specific manner, mimicking the inhibition and regulation of natural enzymes. We demonstrate sub-micromolar inhibition by a histidine-containing inhibitor peptide, taking advantage of cooperative supramolecular assembly and inorganic coordination.

引用

收藏

页码：7492 / 7494

页数：3

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