Synthesis of β-carbolines using microwave-assisted aza-Wittig methodology in ionic liquids

被引：8
作者：
Fresneda, Pilar M. [1 ]
Antonio Blazquez, Jose [1 ]
机构：
[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30100 Murcia, Spain
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 21期
关键词：
beta-Carbolines; Iminophosphoranes; Aza-Wittig reaction; Microwave irradiation; Ionic liquids; PALLADIUM-CATALYZED IMINOANNULATION; ORGANIC-SYNTHESIS; GAMMA-CARBOLINES; MARINE ORIGIN; ANTITUMOR AGENTS; DERIVATIVES; ALKALOIDS; HETEROCYCLES; RING; BIOACTIVITY;
D O I：
10.1016/j.tetlet.2012.03.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The improved preparation of 1-substituted-beta-carbolines is reported using microwave-assisted aza-Wittig/electrocyclic ring-closure reaction with ionic liquids as solvent. In all cases an unprecedented N-methoxymethyl group (MOM) deprotection is observed. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2618 / 2621
页数：4
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