Synthesis of β-carbolines using microwave-assisted aza-Wittig methodology in ionic liquids

被引：8

作者：

Fresneda, Pilar M. ^{[1
]}

Antonio Blazquez, Jose ^{[1
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30100 Murcia, Spain

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 21期

关键词：

beta-Carbolines; Iminophosphoranes; Aza-Wittig reaction; Microwave irradiation; Ionic liquids; PALLADIUM-CATALYZED IMINOANNULATION; ORGANIC-SYNTHESIS; GAMMA-CARBOLINES; MARINE ORIGIN; ANTITUMOR AGENTS; DERIVATIVES; ALKALOIDS; HETEROCYCLES; RING; BIOACTIVITY;

D O I：

10.1016/j.tetlet.2012.03.049

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The improved preparation of 1-substituted-beta-carbolines is reported using microwave-assisted aza-Wittig/electrocyclic ring-closure reaction with ionic liquids as solvent. In all cases an unprecedented N-methoxymethyl group (MOM) deprotection is observed. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2618 / 2621

页数：4

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